6-Amino-4-trifluoromethylquinolin-2(1H)-one
- CAS No.
- 328955-57-3
- Chemical Name:
- 6-Amino-4-trifluoromethylquinolin-2(1H)-one
- Synonyms
- 6-Amino-4-trifluoromethyl-1H-quinolin-2-one;6-Amino-4-trifluoromethylquinolin-2(1H)-one;6-Amino-4-(trifluoromethyl)-2(1H)-quinolinone;2(1H)-Quinolinone, 6-amino-4-(trifluoromethyl)-
- CBNumber:
- CB52516328
- Molecular Formula:
- C10H7F3N2O
- Molecular Weight:
- 228.17
- MDL Number:
- MFCD12828493
- MOL File:
- 328955-57-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
6-Amino-4-trifluoromethylquinolin-2(1H)-one price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | HCH0367643 | 6-AMINO-4-TRIFLUOROMETHYLQUINOLIN-2(1H)-ONE 95.00% | 328955-57-3 | 5MG | $501.39 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0367643 | 6-AMINO-4-TRIFLUOROMETHYLQUINOLIN-2(1H)-ONE 95.00% | 328955-57-3 | 0.25G | $857 | 2021-12-16 | Buy |
| Alichem | 328955573 | 6-Amino-4-trifluoromethylquinolin-2(1H)-one | 328955-57-3 | 1g | $1390.2 | 2021-12-16 | Buy |
| Crysdot | CD11144365 | 6-Amino-4-trifluoromethylquinolin-2(1H)-one 97% | 328955-57-3 | 250mg | $312 | 2021-12-16 | Buy |
| AccelPharmtech | CL1003 | 6-amino-4-(trifluoromethyl)Quinolin-2(1H)-one 95.00% | 328955-57-3 | 1G | $330 | 2021-12-16 | Buy |
6-Amino-4-trifluoromethylquinolin-2(1H)-one Chemical Properties,Uses,Production
Uses
6-Amino-4-(trifluoromethyl)-2(1H)-quinolinone is an intermediate in the synthesis of LGD-2226 (L397615), an orally active potent and selective androgen receptor modulator used in the treatment of muscle wasting and osteoporosis. Show to have an anabolic effect on muscle and bone tissue.
Synthesis
6-Amino-4-trifluoromethylquinolin-2(1H)-one is obtained by reacting Nitro-compound with hydrogen in the presence of 5% Pd/C.
Experimental Procedure：A suspension of the 17.0 g 6-Nitro-4-trifluoromethylquinolin-2(1H)-one in 400 ml ethanol in a 1 L round flask was flushed with argon and 2.0 g 5% Pd/C was added. The mixture was stirred under a hydrogen atmosphere for 2 days. Then filtered through silica and washed with 1500 mL ethanol. The filtrate was evaporated under vacuum to yield 14.0 g of a bright yellow solid 6-Amino-4-trifluoromethylquinolin-2(1H)-one (92%).
6-Amino-4-trifluoromethylquinolin-2(1H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
6-Amino-4-trifluoromethylquinolin-2(1H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | Lingzhiyue@aliyun.com | China | 3145 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2229 | 55 |
| Chengdu NoVi Biotechnology Co., Ltd. | 028-81458053 | novibiotech@163.com sales@novi-biotech.com | China | 226 | 55 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9793 | 50 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 13496 | 58 |
| Nanjing River Chemical Co., Ltd. | 13951936332 18305166317 | info@serpharm.com | China | 493 | 55 |