ChemicalBook >> CAS DataBase List >>LX-4211
LX-4211
- CAS No.
- 1018899-04-1
- Chemical Name:
- LX-4211
- Synonyms
- Sotagliflozin;β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034;LX421;LX-4211;CS-1853;SOTA-009;LP 802034;EOS-61381;LX4211/LX-4211
- CBNumber:
- CB52516025
- Molecular Formula:
- C21H25ClO5S
- Molecular Weight:
- 424.94
- MDL Number:
- MFCD22493506
- MOL File:
- 1018899-04-1.mol
Last updated:2024-12-18 17:20:10
| Boiling point | 607.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:84.0(Max Conc. mg/mL);197.67(Max Conc. mM) Ethanol:17.0(Max Conc. mg/mL);40.01(Max Conc. mM) |
| pka | 12.87±0.70(Predicted) |
| form | Powder |
| color | White to off-white |
| InChIKey | QKDRXGFQVGOQKS-WFCPIQDQNA-N |
| SMILES | [C@@H]1(C2=CC=C(Cl)C(CC3=CC=C(OCC)C=C3)=C2)O[C@H](SC)[C@@H](O)[C@H](O)[C@H]1O |&1:0,19,22,24,26,r| |
| FDA UNII | 6B4ZBS263Y |
| NCI Drug Dictionary | sotagliflozin |
| ATC code | A10BK06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H373 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P260-P314-P501 | |||||||||
| NFPA 704 |
|
LX-4211 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 25mg | $573 | 2024-03-01 | Buy |
| ApexBio Technology | A3567 | LX-4211 | 1018899-04-1 | 5mg | $165 | 2021-12-16 | Buy |
LX-4211 Chemical Properties,Uses,Production
Uses
Sotagliflozin is used for the treatment of patients with type 1 diabetes mellitus.
Clinical Use
Two of the current SGLT-2 inhibitors (canagliflozin and LX-4211) have effects on SGLT-1. LX-4211 is a dual SGLT1/2 inhibitor and higher doses of canagliflozin transiently inhibit SGLT-1 in the gut due to high canagliflozin concentrations within the intestinal lumen during the period of drug absorption.
Synthesis
Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.
Sotagliflozin synthesis
Synthesis of LX-4211 from β-L-Xylopyranoside, Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-, 2,3,4-triacetate,(5S)-
LX-4211 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 260)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 75 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1010 | 58 |
| Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 861 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29793 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 8778 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
Related articles
- How to synthesize Sotagliflozin?
- Sotagliflozin (LX-4211) is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (....
- Jan 16，2024
View Lastest Price from LX-4211 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-10 | LX-4211
1018899-04-1
|
US $999.00-900.00 / kg | 0.0010000000474974513kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2025-01-06 | LX-4211
1018899-04-1
|
US $1.00 / g | 1g | 98% | 1000 | Apeloa production Co.,Limited | |
 |
2024-12-17 | LX-4211
1018899-04-1
|
US $100.00 / KG | 1KG | 99% | 1 T | Hebei Lingding Biotechnology Co., Ltd. |
1018899-04-1(LX-4211)Related Search:
LX-4211
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol
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(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034
β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-
UNII-6B4ZBS263Y
Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034
LX-4211|||LP-802034
Bifeprunox Impurity 42
1018899-04-1
C21H25ClO5S
C21H25O5ClS