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ChemicalBook >> CAS DataBase List >>rotundine

rotundine

CAS No.
483-14-7
Chemical Name:
rotundine
Synonyms
Hyndarine;Gindarine;(-)-Gindarine;ROTUNDINE 98+%;ROTUNDINE (RG);Rotundine?, BR;(S)-Tetrahydrop;Rafoxanide Impurity 3;(S)-Tetrahydropalmitine;(-)-S-TetrahydropalMatine
CBNumber:
CB4947141
Molecular Formula:
C21H25NO4
Molecular Weight:
355.43
MDL Number:
MFCD03265591
MOL File:
483-14-7.mol
Last updated:2024-10-28 23:16:16

rotundine Properties

Melting point 141-143°C
storage temp. Sealed in dry,2-8°C
solubility insoluble in H2O; ≥16 mg/mL in DMSO; ≥2.95 mg/mL in EtOH with gentle warming and ultrasonic
form powder to crystal
Boiling point 482.9±45.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
pka 6.53±0.20(Predicted)
color White to Light yellow
λmax 280nm(lit.)
CAS DataBase Reference 483-14-7
FDA UNII 3X69CO5I79

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H227
Precautionary statements  P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235
RTECS  HQ1792500
HS Code  2933.99.9000
NFPA 704
0
2 0

rotundine price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T3311 L-Tetrahydropalmatine >98.0%(HPLC) 483-14-7 250mg $89 2024-03-01 Buy
Cayman Chemical 20535 L-Tetrahydropalmatine ≥98% 483-14-7 25mg $32 2024-03-01 Buy
Cayman Chemical 20535 L-Tetrahydropalmatine ≥98% 483-14-7 50mg $48 2024-03-01 Buy
Cayman Chemical 20535 L-Tetrahydropalmatine ≥98% 483-14-7 100mg $63 2024-03-01 Buy
Cayman Chemical 20535 L-Tetrahydropalmatine ≥98% 483-14-7 250mg $78 2024-03-01 Buy
Product number Packaging Price Buy
T3311 250mg $89 Buy
20535 25mg $32 Buy
20535 50mg $48 Buy
20535 100mg $63 Buy
20535 250mg $78 Buy

rotundine Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Rotundine is an analgesic drug found in Chinese herbal medicine, used to treat heart disease and liver damage.

Definition

ChEBI: A berberine alkaloid obtained by formal addition of two molecules of hydrogen to the pyridine ring of palmatine.

Biological Activity

levo-tetrahydropalmatine (l-thp) is an active herbal constituent of preparations containing plant species of the genera stephania and corydalis. in china, it has been approved and used for a number of clinical indications under the drug name rotundine.

in vitro

in contrast to other thpb derivatives, l-thp is an antagonist at both of d1 and d2 receptors. the ki values for l-thp at d1 and d2 dopamine receptors are approximately 124 nm (d1) and 388 nm (d2), while the ic50 values are 166 nm and 1.4 μm for d1 and d2, respectively. the relatively high affinity of l-thp at d1 vs. d2 receptors, distinguishes it from other available dopamine receptor antagonist drugs (e.g., haloperidol) [1].

in vivo

it has been found that l-thp produces dose-dependent reductions in locomotor activity and operant responding for non-drug reinforcers in rats [1].

References

[1] wang jb, mantsch jr. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. future med chem. 2012 feb;4(2):177-86.

rotundine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3619 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083 scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Shanghai Standard Technology Co., Ltd.
18502101150 ft-sales@nature-standard.com CHINA 1923 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17365 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32002 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10319 58

View Lastest Price from rotundine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rotundine pictures 2024-10-28 Rotundine
483-14-7
US $31.00-98.00 / mg 99.8% 10g TargetMol Chemicals Inc.
L-Tetrahydropalmatine    pictures 2023-02-24 L-Tetrahydropalmatine
483-14-7
US $0.00 / mg 5mg Analytical Standard 10 g Shanghai Standard Technology Co., Ltd.
L-Tetrahydropalmatine pictures 2022-02-19 L-Tetrahydropalmatine
483-14-7
US $0.00 / KG 1KG 99.5% 100 tons Honest Joy Holdings Limited
  • Rotundine pictures
  • Rotundine
    483-14-7
  • US $31.00-98.00 / mg
  • 99.8%
  • TargetMol Chemicals Inc.

rotundine Spectrum

6H-Dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)- ROTUNDINE 98+% (-)-Gindarine (13aS)-2,3,9,10-Tetramethoxy-5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quinolizine (S)-Tetrahydropalmitine [13aS,(-)]-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine Gindarine (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline TETRAHYDROPALMATINE, L-(P) (-)-S-TetrahydropalMatine (S)-Tetrahydrop O,O-DiMethyl-N-deMethyl-cyclanoline ROTUNDINE (RG) Rotundine?, BR (13aS)-2,3,9,10-Tetramethoxy-5,8,13,13a-tetrahydro-6H-dibenzo[a,g]quinolizine (S)-2,3,9,10-Tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[3,2-a]isoquinoline Hyndarine Rafoxanide Impurity 3 483-14-7 Intermediates & Fine Chemicals Pharmaceuticals Inhibitors