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1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide

CAS No.
1917294-46-2
Chemical Name:
1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide
Synonyms
PF4745637;PF 4745637;PF-4745637;PF-04746537;PF-04745637;1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide;1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide;Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]-;PF04745637,Inhibitor,bowel,TRPA1,disease,inhibit,respiratory,PF-04745637,Transient receptor potential channels,inflammatory,TRP Channel,skin
CBNumber:
CB43340668
Molecular Formula:
C27H32ClF3N2O2
Molecular Weight:
509.0033896
MDL Number:
MFCD31617910
MOL File:
1917294-46-2.mol
Last updated:2024-10-28 23:16:16

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Properties

Boiling point 651.8±55.0 °C(Predicted)
Density 1.281±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 12.14±0.20(Predicted)
form Solid
color White to off-white

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Chemical Properties,Uses,Production

Biological Activity

PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1]. Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].

References

[1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32024 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4456 55
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 4989 55
ATK CHEMICAL COMPANY LIMITED 3429815786 13301662590 sales@atkchemical.com China 9993 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 6521 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 7480 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29786 68

View Lastest Price from 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-04745637 pictures 2024-10-28 PF-04745637
1917294-46-2
 US $67.00-207.00 / mg 99.3% 10g TargetMol Chemicals Inc.
  • PF-04745637 pictures
  • PF-04745637
    1917294-46-2
  • US $67.00-207.00 / mg
  • 99.3%
  • TargetMol Chemicals Inc.

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Spectrum

1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide PF-4745637 PF4745637 PF 4745637 1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide PF-04745637 PF-04746537 PF04745637,Inhibitor,bowel,TRPA1,disease,inhibit,respiratory,PF-04745637,Transient receptor potential channels,inflammatory,TRP Channel,skin Cyclopentanecarboxamide, 1-(4-chlorophenyl)-N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]- 1917294-46-2