CARM1-IN-1
- CAS No.
- 1020399-49-8
- Chemical Name:
- CARM1-IN-1
- Synonyms
- CARM1-IN-1;CARM1-IN-7g;CARM1 inhibitor 1;PRMT4/CARM1 Inhibitor;CARM1-IN-1, 10 mM in DMSO;4-Piperidinone, 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-
- CBNumber:
- CB43034459
- Molecular Formula:
- C26H21Br2NO3
- Molecular Weight:
- 555.26
- MDL Number:
- MOL File:
- 1020399-49-8.mol
- MSDS File:
- SDS
| Boiling point | 659.8±55.0 °C(Predicted) |
|---|---|
| Density | 1.647±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL; Ethanol: 0.25 mg/mL |
| form | A crystalline solid |
| pka | 7.77±0.35(Predicted) |
| color | Yellow to orange |
| UNSPSC Code | 12352200 |
| NACRES | NA.28 |
CARM1-IN-1 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11033 | PRMT4/CARM1 Inhibitor ≥95% | 1020399-49-8 | 500μg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 11033 | PRMT4/CARM1 Inhibitor ≥95% | 1020399-49-8 | 1mg | $129 | 2024-03-01 | Buy |
| Cayman Chemical | 11033 | PRMT4/CARM1 Inhibitor ≥95% | 1020399-49-8 | 5mg | $553 | 2024-03-01 | Buy |
| ChemScene | CS-3970 | CARM1-IN-1 | 1020399-49-8 | 50mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-3970 | CARM1-IN-1 | 1020399-49-8 | 5mg | $100 | 2021-12-16 | Buy |
CARM1-IN-1 Chemical Properties,Uses,Production
Uses
CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM). CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity[1].
Biological Activity
Cell permeable: yes', 'Primary Target
PRMT4', 'Reversible: yes', 'Secondary Target
SET7', 'Target IC50: CARM1-mediated methylation over PRMT1 and SET7 (IC60 = 7.1, 63 and 943 μM,
IC 50
PRMT4
References
[1] Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32. DOI:10.1021/jm200453n
CARM1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
View Lastest Price from CARM1-IN-1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | CARM1-IN-1
1020399-49-8
|
US $31.00-129.00 / mg | 97.35% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-27 | CARM1-IN-1
1020399-49-8
|
US $31.00-129.00 / mg | 97.35% | 10g | TargetMol Chemicals Inc. |
-
- CARM1-IN-1
1020399-49-8
- US $31.00-129.00 / mg
- 97.35%
- TargetMol Chemicals Inc.
-
- CARM1-IN-1
1020399-49-8
- US $31.00-129.00 / mg
- 97.35%
- TargetMol Chemicals Inc.