Rpaf-ah
- CAS No.
- 208576-22-1
- Chemical Name:
- Rpaf-ah
- Synonyms
- Pafase;Rpaf-ah;Epafipase;PAF-AH human;PAF 2-acylhydrolase;Paf acetylhydrolase;Epafipase [usan:inn];LDL-associated phospholipase A2;Deacetylase, 1-alkyl-2-acetyllecithin (human);2-acetyl-1-alkylglycerophosphocholine esterase
- CBNumber:
- CB42493219
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | lyophilized |
| color | white |
| biological source | human |
| FDA UNII | 369989188P |
| UNSPSC Code | 12352202 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
Rpaf-ah price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP3136 | PAF-AH human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture | 208576-22-1 | 20μG | $362 | 2024-03-01 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| SRP3136 | 20μG | $362 | Buy |
Rpaf-ah Chemical Properties,Uses,Production
Uses
Antiallergenic; antiasthmatic (PAF antagonist [PAF acetylhydrolasemphor.].
General Description
Recombinant PAF-AH is a 420 amino acid glycoprotein which migrates with an apparent molecular mass of 47-55kDa by SDS-PAGE analysis.
Biochem/physiol Actions
Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet activating factor acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL (low density lipoprotein) particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids. High levels of PAF-AH in plasma can be an indication of resistant hypertension. Polymorphism in PAF-AH gene at A379V might be linked with ischemic stroke susceptibility.
Rpaf-ah Preparation Products And Raw materials
Raw materials
Preparation Products
Rpaf-ah Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Leon Biological Technology Co., Ltd. | 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 | liugang@njpeptide.com | China | 9980 | 55 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
| amyjetsci | 027-59626688 18771149750 | sales@amyjet.com | China | 3002 | 58 |
| Merck KGaA | (+86) 21 2033 8288 | sigmaname@qq.com | CHINA | 292394 | 58 |
| Supplier | Advantage |
|---|---|
| Nanjing Leon Biological Technology Co., Ltd. | 55 |
| Nanjing Peptide Biotech Ltd. | 55 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | 58 |
| amyjetsci | 58 |
| Merck KGaA | 58 |