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ChemicalBook >> CAS DataBase List >>YS 49

YS 49

CAS No.
132836-42-1
Chemical Name:
YS 49
Synonyms
YS 49;CS-884;YS 49;YS49;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate;inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
CBNumber:
CB41390234
Molecular Formula:
C20H20BrNO2
Molecular Weight:
386.2823
MDL Number:
MFCD20926418
MOL File:
132836-42-1.mol
MSDS File:
SDS
Last updated:2024-10-31 18:15:48

YS 49 Properties

storage temp. 2-8°C
solubility H2O: >10mg/mL
form solid
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Hazard Codes  Xn,N
Risk Statements  22-50
Safety Statements  61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
NFPA 704
0
2 0

YS 49 price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y1521 YS-49 monohydrate ≥98% (HPLC) 132836-42-1 5mg $213 2022-05-15 Buy
Axon Medchem Axon1685 YS49 98% 132836-42-1 10mg $148.5 2021-12-16 Buy
AK Scientific 3028AH 1-(Naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diolhydrobromide 132836-42-1 1mg $152 2021-12-16 Buy
ChemScene CS-1002 YS-49 95.38% 132836-42-1 10mg $158 2021-12-16 Buy
ChemScene CS-2288 YS-49 monohydrate >98.0% 132836-42-1 10mg $158 2021-12-16 Buy
Product number Packaging Price Buy
Y1521 5mg $213 Buy
Axon1685 10mg $148.5 Buy
3028AH 1mg $152 Buy
CS-1002 10mg $158 Buy
CS-2288 10mg $158 Buy

YS 49 Chemical Properties,Uses,Production

Biological Activity

YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.

in vitro

YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC 50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

Cell Viability Assay

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells)
Incubation Time: 18 hours
Result: Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC 50 values of 22 and 30 μM, respectively .

Western Blot Analysis

Cell Line: RAVSMC and RAW 264.7 cells
Concentration: 10 μΜ, 30 μΜ and 100 μΜ
Incubation Time: 18 hours
Result: Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.

in vivo

YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>

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Animal Model: Male Sprague Dawley rats (250-300 g)
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 8 hours
Result: Serum NOx levels were significantly reduced.

YS 49 Preparation Products And Raw materials

Raw materials

Preparation Products

YS 49 Suppliers

Global( 75)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32070 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30241 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38463 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58

View Lastest Price from YS 49 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
YS-49 pictures 2024-10-31 YS-49
132836-42-1
 US $41.00-92.00 / mg 99.42% 10g TargetMol Chemicals Inc.
YS-49 pictures 2024-10-31 YS-49
132836-42-1
 US $41.00-92.00 / mg 99.42% 10g TargetMol Chemicals Inc.
  • YS-49 pictures
  • YS-49
    132836-42-1
  • US $41.00-92.00 / mg
  • 99.42%
  • TargetMol Chemicals Inc.
  • YS-49 pictures
  • YS-49
    132836-42-1
  • US $41.00-92.00 / mg
  • 99.42%
  • TargetMol Chemicals Inc.

YS 49 Spectrum

YS 49 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide CS-884 YS 49;YS49 inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor 132836-42-1 C20H19NO2HBr Akt mTOR PI3K PI3K/Akt/mTOR