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ChemicalBook >> CAS DataBase List >>(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride

CAS No.
38176-02-2
Chemical Name:
(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride
Synonyms
LU 33925;NSC 632821;CCRIS 2680;R-Verapamil HCl;Verapamil impurity 31;Dexverapamil monohydrochloride;R(+)-Verapamil monohydrochloride;R(+)-Verapamil monohydrochloride hydrate;R(+)-Verapamil hydrate monohydrochloride;R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE
CBNumber:
CB3931684
Molecular Formula:
C27H41ClN2O5
Molecular Weight:
509.07784
MDL Number:
MFCD11046028
MOL File:
38176-02-2.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Properties

Melting point 129-131?C
storage temp. Refrigerator
solubility H2O: >30mg/mL
form powder
color white
optical activity [α]22/D +9.6°, c = 0.5 in ethanol(lit.)
Water Solubility H2O: >30mg/mL
ethanol: soluble
FDA UNII B0P742MK5O
UNSPSC Code 12161501
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331
Precautionary statements  P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  22-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V106 R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder 38176-02-2 5mg $268 2024-03-01 Buy
Sigma-Aldrich V106 R(+)-Verapamil monohydrochloride hydrate ≥98% (HPLC), powder 38176-02-2 25mg $1010 2024-03-01 Buy
TRC V124990 (R)-(+)-VerapamilHydrochloride 38176-02-2 2mg $335 2021-12-16 Buy
ChemScene CS-0111666 (R)-Verapamil(hydrochloride) 98.54% 38176-02-2 10mg $360 2021-12-16 Buy
Biosynth Carbosynth ID28684 (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride 38176-02-2 2mg $578.1 2021-12-16 Buy
Product number Packaging Price Buy
V106 5mg $268 Buy
V106 25mg $1010 Buy
V124990 2mg $335 Buy
CS-0111666 10mg $360 Buy
ID28684 2mg $578.1 Buy

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Chemical Properties,Uses,Production

Chemical Properties

Colourless solid

Uses

Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells.

Uses

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

Definition

ChEBI: Dexverapamil hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of dexverapamil and hydrogen chloride. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil hydrochloride exhibits lower calcium antagonistic activity and toxicity than racemic verapamil hydrochloride. It has a role as an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor. It contains a dexverapamil(1+). It is an enantiomer of a (S)-verapamil hydrochloride.

Biochem/physiol Actions

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride Suppliers

Global( 40)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6795 65
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14055 65
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80

38176-02-2((+)-[3-cyano-3-(3,4-dimethoxyphenyl)hex-6-yl](5,6-dimethoxyphenethyl)methylammonium chloride)Related Search:

R(+)-VERAPAMIL MONOHYDROCHLORIDE MONOHYDRATE Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (aR)- (9CI) Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, monohydrochloride, (R)- Dexverapamil monohydrochloride LU 33925 NSC 632821 Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (alphaR)- Benzeneacetonitrile, alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (R)- R(+)-Verapamil hydrate monohydrochloride (+)-[3-cyano-3-(3,4-diMethoxyphenyl)hex-6-yl](5,6- (αR)-α-[3-[[2-(3,4-DiMethoxyphenyl)ethyl]MethylaMino]propyl]-3,4-diMethoxy-α-(1-Methylethyl)-benzeneacetonitrile Hydrochloride R(+)-Verapamil monohydrochloride hydrate R(+)-Verapamil monohydrochloride R-Verapamil HCl (2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride CCRIS 2680 Verapamil impurity 31 38176-02-2 C27H38N2O4HClH2O Drug Efflux Pumps Modulators for MDR/TAP Transporters Amines Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Multi-Drug Resistance