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ChemicalBook >> CAS DataBase List >>H-7 DIHYDROCHLORIDE

H-7 DIHYDROCHLORIDE

CAS No.
108930-17-2
Chemical Name:
H-7 DIHYDROCHLORIDE
Synonyms
H-7;H-7 DIHYDROCHLORIDE;H-7 (hydrochloride);H-7 dihydrochloride,98%;H7 dihydrochloride,H 7 dihydrochloride;Protein kinase inhibitor H-7 dihydrochloride;1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL;1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL
CBNumber:
CB3725838
Molecular Formula:
C14H19Cl2N3O2S
Molecular Weight:
364.29
MDL Number:
MFCD00036961
MOL File:
108930-17-2.mol
MSDS File:
SDS
Last updated:2024-11-06 15:28:16

H-7 DIHYDROCHLORIDE Properties

Melting point 215-225 °C
storage temp. 2-8°C
solubility H2O: 20 mg/mL
form Light yellow lyophilized solid
color White to Off-White
BRN 5840763
CAS DataBase Reference 108930-17-2(CAS DataBase Reference)
FDA UNII 55VT8U9HB1

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
F  10

H-7 DIHYDROCHLORIDE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I7016 H-7 dihydrochloride ≥98% (HPLC) 108930-17-2 5mg $136.8 2024-03-01 Buy
Alfa Aesar J61697 H-7 dihydrochloride 108930-17-2 10mg $165.65 2024-03-01 Buy
Alfa Aesar J61697 H-7 dihydrochloride 108930-17-2 50mg $721 2023-06-20 Buy
Cayman Chemical 21434 H-7 (hydrochloride) ≥98% 108930-17-2 5mg $57 2024-03-01 Buy
Cayman Chemical 21434 H-7 (hydrochloride) ≥98% 108930-17-2 10mg $95 2024-03-01 Buy
Product number Packaging Price Buy
I7016 5mg $136.8 Buy
J61697 10mg $165.65 Buy
J61697 50mg $721 Buy
21434 5mg $57 Buy
21434 10mg $95 Buy

H-7 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Uses

A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases

Uses

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Definition

ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

General Description

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

Biochem/physiol Actions

Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

storage

Store at RT

H-7 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

H-7 DIHYDROCHLORIDE Suppliers

Global( 74)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30236 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32343 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32321 50
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611 China 9891 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80

View Lastest Price from H-7 DIHYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Protein kinase inhibitor H-7 dihydrochloride pictures 2024-11-06 Protein kinase inhibitor H-7 dihydrochloride
108930-17-2
 US $45.00-163.00 / mg 99.54% 10g TargetMol Chemicals Inc.
H-7 DIHYDROCHLORIDE H-7 (+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE 1-(5-ISOQUINOLINYLSULFONYL)-2-METHYL-PIPERAZINE DIHYDROCHLORIDE (+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 2HCL (-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE, DI-HCL SALT (+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine 2HCl H-7 dihydrochloride,98% H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride 5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline Hydrochloride H-7 (hydrochloride) H7 dihydrochloride,H 7 dihydrochloride 5-((2-Methylpiperazin-1-yl)sulfonyl)isoquinoline dihydrochloride Protein kinase inhibitor H-7 dihydrochloride 108930-17-2 C14H19Cl2N3O2S Cell Biology Serine/Threonine Kinase Inhibitors Kinase/Phosphatase Biology Protein kinase A and protein kinase C (PKA and PKC) BioChemical Cell Signaling and Neuroscience Protein Kinase Inhibitors and Activators