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ChemicalBook >> CAS DataBase List >>Mc-Val-Cit-PABC-PNP

Mc-Val-Cit-PABC-PNP

CAS No.
159857-81-5
Chemical Name:
Mc-Val-Cit-PABC-PNP
Synonyms
Mc-Val-Cit-PABC-PNP;MC-Val-Cit-PAB-PNP;MC-VC-PAB-PNP;MC-Val-Cit-PABC;L-Ornithinamide;MC-VAL-CIT-PAB-PNB;SKL361;CS-1787;AK-32171;VCMMAE linker
CBNumber:
CB32667895
Molecular Formula:
C35H43N7O11
Molecular Weight:
737.76
MDL Number:
MFCD22200431
MOL File:
159857-81-5.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02

Mc-Val-Cit-PABC-PNP Properties

Boiling point 1034.5±65.0 °C(Predicted)
Density 1.338±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMF: 25 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form A crystalline solid
pka 13.24±0.70(Predicted)
color Off-white to light yellow
InChIKey UQRQGHMQKAXOTE-DHIFEGFHSA-N
SMILES C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1
FDA UNII QY7B3AFP6T
UNSPSC Code 12352200
NACRES NA.22

Mc-Val-Cit-PABC-PNP price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23881 Mc-Val-Cit-PABC-PNP ≥98% 159857-81-5 1mg $32 2024-03-01 Buy
Cayman Chemical 23881 Mc-Val-Cit-PABC-PNP ≥98% 159857-81-5 5mg $139 2024-03-01 Buy
Cayman Chemical 23881 Mc-Val-Cit-PABC-PNP ≥98% 159857-81-5 10mg $243 2024-03-01 Buy
Iris Biotech GmbH ADC1110 MC-Val-Cit-PAB-PNP 159857-81-5 250mg $472.5 2021-12-16 Buy
AK Scientific 3805AH Mc-Val-Cit-PABC-PNP 159857-81-5 100mg $594 2021-12-16 Buy
Product number Packaging Price Buy
23881 1mg $32 Buy
23881 5mg $139 Buy
23881 10mg $243 Buy
ADC1110 250mg $472.5 Buy
3805AH 100mg $594 Buy

Mc-Val-Cit-PABC-PNP Chemical Properties,Uses,Production

Description

Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin or monomethyl auristatin E (MMAE; ). ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.

Uses

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates.

General Description

Mc-Val-Cit-PABC-PNP is chemically known as L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-, an enzymatically cleavable linker for antibody-drug conjugates (ADCs). Other ADCs linkers include MC-Val-Cit-PAB-PNP, Mc-Val-Ala-PAB-PNP, Mc-Val-Cit-PABOH, and VcMMAE.

159857-80-4
5070-13-3
159857-81-5
Synthesis of Mc-Val-Cit-PABC-PNP from MC-Val-Cit-PAB and BIS(4-NITROPHENYL) CARBONATE
Global( 230)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemExpress
+86-021-58950125 +86-021-58950125; info@chemexpress.com China 780 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20267 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32965 60
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 18419 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58

View Lastest Price from Mc-Val-Cit-PABC-PNP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MC-Val-Cit-PABC-PNP pictures 2024-11-19 MC-Val-Cit-PABC-PNP
159857-81-5
 US $29.00 / mg 99.13% 10g TargetMol Chemicals Inc.
MC-Val-Cit-PAB-PNP pictures 2024-03-29 MC-Val-Cit-PAB-PNP
159857-81-5
 US $0.00 / g 5g >97.00% 5g Xian confluore Biological Technology Co., Ltd.
L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- pictures 2023-12-23 L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-
159857-81-5
 US $50.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
  • MC-Val-Cit-PAB-PNP pictures
  • MC-Val-Cit-PAB-PNP
    159857-81-5
  • US $0.00 / g
  • >97.00%
  • Xian confluore Biological Technology Co., Ltd.
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate Mc-Val-Cit-PABC-PNP L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate MC-Val-Cit-PAB-PNP (ADC peptide linker) 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl 4-nitrophenyl carbonate MC-VC-PAB-PNP,Mc-Val-Cit-PABC-PNP MC-VAL-CIT-PABC-PNP;MC-VC-PAB-PNP;MC-VAL-CIT-PAB-PNB;MC-VAL-CIT-PAB-PNP [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate AK-32171 SKL361 L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- ISO 9001：2015 REACH N-(6-Maleimidocaproyl)-L-valyl-N5-carbamoyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl 4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl 4-nitrophenyl carbonate,linker L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(5-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- JACS-159857-81-5 VCMMAE linker N-[6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl]-L-valyl-N5-carbamoyl-N[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide [4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate Mc-Val-Cit-PABC-PNP(VCMMAE linker) CS-1787 Mc-Val-Cit-PABC-PNP (Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate) L-Ornithinamide MC-Val-Cit-PABC Mc-Val-Cit-PABC-PNP MC-VC-PAB-PNP MC-VAL-CIT-PAB-PNB MC-Val-Cit-PAB-PNP 1H-Indene-1,3(2H)-dione,5,8-dichloro- N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-L-ornithinamide Top quality 159857-81-5 MC-Val-Cit-PABC (4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido]pentanamido]phenyl)methyl 4-nitrophenyl carbonate Ornithine Impurity 13 Inhibitor|||inhibit|||MC-Val-Cit-PABC-PNP|||Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate|||Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate|||ADC Linkers|||MC Val Cit PABC PNP|||Antibody-drug conjugate 159857-81-5 159857-81-6 C35H43N7O11 ADCs ADCs Linkers ADC-Linker ADC-Linkers