INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2621391-31-7
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- Biotin-PEG12-DBCO;BCO-NHCO-PEG12-biotin;1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-N-(3-{2-azatricyclo[10.4.0.0\\u2074,\\u2079]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-3-oxopropyl)-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-amide
- CBNumber:
- CB312291862
- Molecular Formula:
- C55H83N5O16S
- Molecular Weight:
- 1102.35
- MDL Number:
- MOL File:
- 2621391-31-7.mol
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Uses
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG12-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
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