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ChemicalBook >> CAS DataBase List >>(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

CAS No.
42399-49-5
Chemical Name:
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Synonyms
HYDROXY LACTAM;(2S,3S)-DHMB;96.0%(LC&DiltiazeM IMpurity E;(2S) -cis-hydroxy lactam;CIS(+) HYDROXY DILTIAZEM;(2S,3S)-3-Hydroxy-2-(4-methoxypheny;Diltiazem Hydrochloride EP Impurity E;Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem;3-hydroxy-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
CBNumber:
CB2319542
Molecular Formula:
C16H15NO3S
Molecular Weight:
301.36
MDL Number:
MFCD01321316
MOL File:
42399-49-5.mol
Last updated:2024-11-13 18:13:23

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Properties

Melting point 203-206 °C(lit.)
alpha 112 º (c=0.5 in MeOH)
Boiling point 545.4±50.0 °C(Predicted)
Density 1.2458 (rough estimate)
refractive index 114 ° (C=0.5, MeOH)
storage temp. Sealed in dry,2-8°C
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
pka 12.37±0.40(Predicted)
form Solid
color Off-White
InChIKey LHBHZALHFIQJGJ-CABCVRRESA-N
CAS DataBase Reference 42399-49-5(CAS DataBase Reference)
FDA UNII 6RN4N3305M

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29349990
NFPA 704
0
2 0

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D3661 (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one >96.0%(HPLC)(N) 42399-49-5 5g $36 2024-03-01 Buy
TCI Chemical D3661 (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one >96.0%(HPLC)(N) 42399-49-5 25g $111 2024-03-01 Buy
TRC D288450 Des[3-Acetyl-5-(2-dimethylamino)ethyl]Diltiazem 42399-49-5 50mg $80 2021-12-16 Buy
Biosynth Carbosynth FD21106 Des[3-acetyl-5-(2-dimethylamino)ethyl] diltiazem 42399-49-5 50g $95 2021-12-16 Buy
Biosynth Carbosynth FD21106 Des[3-acetyl-5-(2-dimethylamino)ethyl] diltiazem 42399-49-5 25g $55 2021-12-16 Buy
Product number Packaging Price Buy
D3661 5g $36 Buy
D3661 25g $111 Buy
D288450 50mg $80 Buy
FD21106 50g $95 Buy
FD21106 25g $55 Buy

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Chemical Properties,Uses,Production

Chemical Properties

white to slightly beige powder

Uses

A key intermediate for Diltiazem (D460620) synthesis.

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 202)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18747 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29812 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17365 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34553 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22883 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15354 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58

View Lastest Price from (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Hydroxy Lactam pictures 2024-11-13 Hydroxy Lactam
42399-49-5
 US $0.00 / KG 1KG 99% 100000KGS Shaanxi Dideu New Materials Co. Ltd
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one pictures 2024-11-11 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
42399-49-5
 US $0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP pictures 2021-07-29 (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP
42399-49-5
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
  • Hydroxy Lactam pictures
  • Hydroxy Lactam
    42399-49-5
  • US $0.00 / KG
  • 99%
  • Shaanxi Dideu New Materials Co. Ltd
(2S-CIS)-(+)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one ,99% DiltiazeM IMpurity E 3-hydroxy-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem 5-benzothiazepin-4(5h)-one,2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-(2s-c CIS-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE (2S-CIS)-(+)-DIHYDRO-3-OH-2-(4-MEO-PH)-1 ,5-BENZOTHIAZEPIN-4(5H)-ONE, 98% (2S,3S)-(+)-3-Hydroxy-2-(4'-Methoxyphenyl)-2.3-Dihydro-1,5-Benzothiazepin-4(5H)-One[Cis-(+)-HydroxyLactam] 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S-cis) (2S-CIS)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN- (2S)-cis-(+)-2， 3-Dihydro-3-hydroxy-2- (4-methoxyphenyl)-1，5-benzothiazepin- 4(5H)-one (cis-Lactam) (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (2S)-2,3-Dihydro-3β-hydroxy-2β-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (2S)-2β-(4-Methoxyphenyl)-3β-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepine-4-one (2S,3S)-DHMB (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one,98% (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one(Dilthiazem hydrochloride) 3-hydroxy-2-(4-methoxyphenyl)-3,5-dihydro-2H-1,5-benzothiazepin-4-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one> (2S,3S)-3-Hydroxy-2-(4-methoxypheny 96.0%(LC& 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S,3S)- (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3,4,5-tet rahydro-1,5-benzothiazepin-4-one (2S,3S)-3-HYDROXY-2-(4-METHOXYPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPIN- (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzo... (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-b 42399-49-5 HYDROXY LACTAM (2S) -cis-hydroxy lactam Diltiazem Hydrochloride EP Impurity E CIS(+) HYDROXY DILTIAZEM Diltiazem EP Impurity E (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3- dihydro-1,5-benzothiazepin-4(5H)-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, ≥ 96.0% 42399-49-5 C16H15NO3S Heterocyclic Building Blocks Others Chiral Building Blocks Asymmetric Synthesis Pharmaceutical Intermediates Chiral Building Blocks Heterocyclic Building Blocks Others Heterocycles series INTERMEDIATESOFDILTIAZEM API intermediates Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds