Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- CAS No.
- 2003260-55-5
- Chemical Name:
- Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-
- Synonyms
- CS-2874;KDM4B-IN-B3;NCGC00244536;KDM4B Inhibitor B3;NCGC00244536(Benzamide);NCGC00244536, 10 mM in DMSO;KDM4B INHIBITOR COMPOUND B3;3-(8-Hydroxyquinolin-6-yl)-N-(3-phenylpropyl)benzamide;Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)-;NCGC 00244536,inhibit,Histone Demethylase,NCGC00244536,Inhibitor,NCGC-00244536
- CBNumber:
- CB23146688
- Molecular Formula:
- C25H22N2O2
- Molecular Weight:
- 382.45
- MDL Number:
- MFCD31382180
- MOL File:
- 2003260-55-5.mol
| Boiling point | 646.9±55.0 °C(Predicted) |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMF:30.0(Max Conc. mg/mL);78.44(Max Conc. mM) DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.86(Max Conc. mM) DMSO:44.22(Max Conc. mg/mL);115.63(Max Conc. mM) Ethanol:1.5(Max Conc. mg/mL);3.92(Max Conc. mM) |
| form | A crystalline solid |
| pka | 4.81±0.40(Predicted) |
| color | Light yellow to green yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18478 | NCGC00244536 | 2003260-55-5 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 18478 | NCGC00244536 | 2003260-55-5 | 25mg | $593 | 2024-03-01 | Buy |
| Cayman Chemical | 18478 | NCGC00244536 | 2003260-55-5 | 5mg | $143 | 2024-03-01 | Buy |
| Cayman Chemical | 18478 | NCGC00244536 | 2003260-55-5 | 10mg | $263 | 2024-03-01 | Buy |
| ChemScene | CS-6877 | NCGC00244536 98.02% | 2003260-55-5 | 5mg | $396 | 2021-12-16 | Buy |
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Chemical Properties,Uses,Production
Uses
NCGC00244536 is a potent KDM4B inhibitor with an IC50 of 10 nM.
Biological Activity
NCGC00244536 is a potent KDM4B inhibitor with IC50 of 10 nM.
in vitro
NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC 50 =40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4 . NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC 50 s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC 50 s.
in vivo
Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. Histological data clearly indicate that NCGC00244536-treated tumors have significant amount of cell apoptosis, necrosis, and fibrosis .
IC 50
KDM4
References
[1] Duan L, et al. KDM4/JMJD2 Histone Demethylase Inhibitors Block Prostate Tumor Growth by Suppressing the Expression of AR and BMYB-Regulated Genes. Chem Biol. 2015 Sep 17;22(9):1185-96. DOI:10.1016/j.chembiol.2015.08.007
Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd. | 0431-80514535 13634302652 | Extension@chemextension.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Daeyeon Chemicals Co., Ltd | 021-64478606 +8615900664856 | daeyeon001@vip.163.com | China | 2062 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38660 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 |
View Lastest Price from Benzamide, 3-(8-hydroxy-6-quinolinyl)-N-(3-phenylpropyl)- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | NCGC00244536
2003260-55-5
|
US $97.00-497.00 / mg | 99.15% | 10g | TargetMol Chemicals Inc. |
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- NCGC00244536
2003260-55-5
- US $97.00-497.00 / mg
- 99.15%
- TargetMol Chemicals Inc.