ChemicalBook >> CAS DataBase List >>N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
- CAS No.
- 1557267-42-1
- Chemical Name:
- N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
- Synonyms
- CS-2348;Avitinib;Avi Tini;Abivertinib;Avitinib (AC0010);Avitinib free base;Avitinib Abivertinib;Avitinib(AC0010/AC0010MA);N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide;N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
- CBNumber:
- CB23051748
- Molecular Formula:
- C26H26FN7O2
- Molecular Weight:
- 487.53
- MDL Number:
- MFCD29089376
- MOL File:
- 1557267-42-1.mol
Last updated:2024-10-29 20:19:27
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Properties
Density | 1.365±0.06 g/cm3(Predicted) |
---|---|
storage temp. | Store at -20°C |
solubility | DMSO:30.0(Max Conc. mg/mL);61.53(Max Conc. mM) |
form | A crystalline solid |
pka | 12.48±0.50(Predicted) |
color | White to off-white |
FDA UNII | CER0OPG92L |
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21387 | Avitinib ≥98% | 1557267-42-1 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 21387 | Avitinib ≥98% | 1557267-42-1 | 5mg | $161 | 2024-03-01 | Buy |
Cayman Chemical | 21387 | Avitinib ≥98% | 1557267-42-1 | 10mg | $283 | 2024-03-01 | Buy |
Cayman Chemical | 21387 | Avitinib ≥98% | 1557267-42-1 | 25mg | $618 | 2024-03-01 | Buy |
AK Scientific | 4573DW | Abivertinib | 1557267-42-1 | 25mg | $785 | 2021-12-16 | Buy |
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Chemical Properties,Uses,Production
Description
Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR. In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.
Uses
Abivertinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). Abivertinib synergistically strengthens anti-leukemia activity of venetoclax in acute myeloid leukemia in BTK-dependent manner.
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 80)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32002 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3461 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38460 | 58 |
View Lastest Price from N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-29 | Avitinib
1557267-42-1
|
US $41.00-117.00 / mg | 100% | 10g | TargetMol Chemicals Inc. | |||
2020-01-10 | N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
1557267-42-1
|
US $1.00 / KG | 1g | 98% | 200kgs | Career Henan Chemical Co |
- Avitinib
1557267-42-1
- US $41.00-117.00 / mg
- 100%
- TargetMol Chemicals Inc.
- N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
1557267-42-1
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
1557267-42-1(N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide)Related Search:
Avitinib
2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
Avi Tini
Avitinib(AC0010/AC0010MA)
Avitinib free base
Avitinib (AC0010)
Abivertinib
CS-2348
Epidermal growth factor receptor,Bruton tyrosine kinase,AC-0010,Avitinib,HER1,Inhibitor,EGFR,Btk,AC 0010,Abivertinib,inhibit,ErbB-1
N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
Avitinib Abivertinib
1557267-42-1
557267-42-1