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ChemicalBook >> CAS DataBase List >>N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide

CAS No.
1557267-42-1
Chemical Name:
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
Synonyms
CS-2348;Avitinib;Avi Tini;Abivertinib;Avitinib (AC0010);Avitinib free base;Avitinib Abivertinib;Avitinib(AC0010/AC0010MA);N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide;N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide
CBNumber:
CB23051748
Molecular Formula:
C26H26FN7O2
Molecular Weight:
487.53
MDL Number:
MFCD29089376
MOL File:
1557267-42-1.mol
Last updated:2024-10-29 20:19:27

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Properties

Density 1.365±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:30.0(Max Conc. mg/mL);61.53(Max Conc. mM)
form A crystalline solid
pka 12.48±0.50(Predicted)
color White to off-white
FDA UNII CER0OPG92L

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21387 Avitinib ≥98% 1557267-42-1 1mg $37 2024-03-01 Buy
Cayman Chemical 21387 Avitinib ≥98% 1557267-42-1 5mg $161 2024-03-01 Buy
Cayman Chemical 21387 Avitinib ≥98% 1557267-42-1 10mg $283 2024-03-01 Buy
Cayman Chemical 21387 Avitinib ≥98% 1557267-42-1 25mg $618 2024-03-01 Buy
AK Scientific 4573DW Abivertinib 1557267-42-1 25mg $785 2021-12-16 Buy
Product number Packaging Price Buy
21387 1mg $37 Buy
21387 5mg $161 Buy
21387 10mg $283 Buy
21387 25mg $618 Buy
4573DW 25mg $785 Buy

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Chemical Properties,Uses,Production

Description

Avitinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). It is selective for EGFR-active and T790M mutations, exhibiting a 298-fold increase in potency compared with wild-type EGFR. In a xenograft model, oral administration of 500 mg/kg avitinib was shown to result in complete remission of tumors with EGFR-active and T790M mutations.

Uses

Abivertinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). Abivertinib synergistically strengthens anti-leukemia activity of venetoclax in acute myeloid leukemia in BTK-dependent manner.

N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 80)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32002 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10319 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38460 58

View Lastest Price from N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Avitinib pictures 2024-10-29 Avitinib
1557267-42-1
 US $41.00-117.00 / mg 100% 10g TargetMol Chemicals Inc.
N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide pictures 2020-01-10 N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide
1557267-42-1
 US $1.00 / KG 1g 98% 200kgs Career Henan Chemical Co
  • Avitinib pictures
  • Avitinib
    1557267-42-1
  • US $41.00-117.00 / mg
  • 100%
  • TargetMol Chemicals Inc.

1557267-42-1(N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide)Related Search:

Avitinib 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]- N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide Avi Tini Avitinib(AC0010/AC0010MA) Avitinib free base Avitinib (AC0010) Abivertinib CS-2348 Epidermal growth factor receptor,Bruton tyrosine kinase,AC-0010,Avitinib,HER1,Inhibitor,EGFR,Btk,AC 0010,Abivertinib,inhibit,ErbB-1 N-{3-[(2-{[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}prop-2-enamide Avitinib Abivertinib 1557267-42-1 557267-42-1