IDO-IN-7
- CAS No.
- 1402837-78-8
- Chemical Name:
- IDO-IN-7
- Synonyms
- IDO-IN-7;Navoximod;Navoximod (NLG919);IDO-IN-7(Navoximod);Reaxys ID: 22999399;Navoximod (GDC-0919;Navoximod free base;Navoximod, 10 mM in DMSO;Navoximod (Synonyms: GDC-0919;GDC-0917;CUDC427;CUDC 427;GDC0917;GDC 0917
- CBNumber:
- CB23048658
- Molecular Formula:
- C18H21FN2O2
- Molecular Weight:
- 316.38
- MDL Number:
- MFCD29472253
- MOL File:
- 1402837-78-8.mol
| Boiling point | 555.4±35.0 °C(Predicted) |
|---|---|
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:100.0(Max Conc. mg/mL);316.09(Max Conc. mM) |
| form | Solid |
| pka | 14.66±0.20(Predicted) |
| color | White to light yellow |
| FDA UNII | 926SHL95NC |
IDO-IN-7 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5088 | Navoximod 99.99% | 1402837-78-8 | 1mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-5088 | Navoximod 99.99% | 1402837-78-8 | 5mg | $560 | 2021-12-16 | Buy |
| ChemScene | CS-5088 | Navoximod 99.99% | 1402837-78-8 | 10mg | $955 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611749 | Navoximod | 1402837-78-8 | 10mg | $1445 | 2021-12-16 | Buy |
| DC Chemicals | DC23982 | Navoximod(GDC-0919;NLG-?919) >98% | 1402837-78-8 | 250mg | $1500 | 2021-12-16 | Buy |
IDO-IN-7 Chemical Properties,Uses,Production
Uses
Navoximod (GDC-0919; NLG-?919) is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.
in vivo
VNavoximod (NLG919) is orally bioavailable (F>70%); and has a favorable pharmacokinetic and toxicity profile. In mice, a single oral administration of Navoximod reduces the concentration of plasma and tissue Kyn by ~50%. In vivo, in mice bearing large established B16F10 tumors, administration of Navoximod markedly enhances the anti-tumor responses of na?ve, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA. In this stringent established-tumor model, Navoximod plus pmel-1/vaccine produce a dramatic collapse of tumor size within 4 days of vaccination (~95% reduction in tumor volume compare to control animals receiving pmel-1/vaccine alone without Navoximod)[1]. When combined with NSC 362856 (TMZ)+radiation therapy (RT), both Navoximod and D-1MT (Indoximod) enhance survival relative to mice treated with TMZ+RT alone[2].
IC 50
IDO: 7 nM (Ki); IDO: 75 nM (EC50)
References
[1] Mario R. Mautino, et al. Abstract 491: NLG919, a novel indoleamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy. AACR 104th Annual Meeting 2013; Apr 6-10, 2013.
[2] Li M, et al. The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma. J Immunother Cancer. 2014 Jul 7;2:21. DOI:10.1186/2051-1426-2-21
[3] Chen Y, et al. An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy. Nat Commun. 2016 Nov 7;7:13443. DOI:10.1038/ncomms13443
IDO-IN-7 Preparation Products And Raw materials
Raw materials
Preparation Products
IDO-IN-7 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38642 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Wuhan rheniuhui Biotechnology Co., Ltd | 18062115889 | 405368533@qq.com | China | 189 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4613 | 55 |
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