GNE-617 (hydrochloride)
- CAS No.
- 2070014-99-0
- Chemical Name:
- GNE-617 (hydrochloride)
- Synonyms
- GNE-617 (hydrochloride)
- CBNumber:
- CB12677081
- Molecular Formula:
- C21H16ClF2N3O3S
- Molecular Weight:
- 463.88
- MDL Number:
- MFCD28167727
- MOL File:
- 2070014-99-0.mol
GNE-617 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1939 | GNE-617hydrochloride 99.15% | 2070014-99-0 | 2mg | $55 | 2021-12-16 | Buy |
| ChemScene | CS-1939 | GNE-617hydrochloride 99.15% | 2070014-99-0 | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-1939 | GNE-617hydrochloride 99.15% | 2070014-99-0 | 10mg | $150 | 2021-12-16 | Buy |
| ApexBio Technology | B1309 | GNE-617hydrochloride | 2070014-99-0 | 2mg | $221 | 2021-12-16 | Buy |
| ApexBio Technology | B1309 | GNE-617hydrochloride | 2070014-99-0 | 5mg | $331 | 2021-12-16 | Buy |
GNE-617 (hydrochloride) Chemical Properties,Uses,Production
Uses
GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.
in vivo
In rats, GNE-617 hydrochloride (administered QD) and GNE-875 (administered BID) are associated with more severe retinal toxicity at similar exposures and dosing duration compared with GMX-1778 (administered BID). The mouse efficacy studies using GNE-617, GNE-618, and GMX-1778 are designed to assess efficacy and opportunistically used to assess retinal toxicity in mice. NAMPTi retinal toxicity is observed with GNE-617 and GMX-1778; however, the different study durations between GNE-617 and GMX-1778 do not allow for direct comparison of retinal toxicity[2].
References
[1] Shames DS, et al. Loss of NAPRT1 Expression by Tumor-specific Promoter Methylation Provides a Novel Predictive Biomarker for NAMPT Inhibitors. Clin Cancer Res. 2013 Dec 15;19(24):6912-23. DOI:10.1158/1078-0432.CCR-13-1186
[2] Zabka TS, et al. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase. Toxicol Sci. 2015 Mar;144(1):163-72. DOI:10.1093/toxsci/kfu268
GNE-617 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
GNE-617 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19905 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4611 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3866 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | +86-0576-88813233 +86-13396860566 | sales@pharm-intermediates.com | China | 1991 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9772 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
View Lastest Price from GNE-617 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | GNE-617 hydrochloride
2070014-99-0
|
US $1598.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- GNE-617 hydrochloride
2070014-99-0
- US $1598.00 / mg
- TargetMol Chemicals Inc.