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ChemicalBook >> CAS DataBase List >>(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

CAS No.
254750-02-2
Chemical Name:
(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
Synonyms
EMricasan;CS-1040;CS-2634;IDN 6556;abs816139;PF 03491390;Emricasan, (IDN-6556;Emricasan, PF 03491390;Emricasan, 10 mM in DMSO;Emricasan(IDN6556,PF03491390)
CBNumber:
CB12514861
Molecular Formula:
C26H27F4N3O7
Molecular Weight:
569.51
MDL Number:
MFCD11840420
MOL File:
254750-02-2.mol
MSDS File:
SDS
Last updated:2025-05-07 21:23:15

(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Properties

Density 1.386
storage temp. -20°C
solubility DMSO:42.0(Max Conc. mg/mL);73.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);175.59(Max Conc. mM)
pka 3.91±0.19(Predicted)
form powder
color white to beige
CAS DataBase Reference 254750-02-2
FDA UNII P0GMS9N47Q
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2227 Emricasan ≥98% (HPLC) 254750-02-2 5mg $128 2024-03-01 Buy
Sigma-Aldrich SML2227 Emricasan ≥98% (HPLC) 254750-02-2 25mg $514 2024-03-01 Buy
Cayman Chemical 22204 Emricasan ≥98% 254750-02-2 1mg $34 2024-03-01 Buy
Cayman Chemical 22204 Emricasan ≥98% 254750-02-2 5mg $76 2024-03-01 Buy
Cayman Chemical 22204 Emricasan ≥95% 254750-02-2 25 mg $253 2024-03-01 Buy
Product number Packaging Price Buy
SML2227 5mg $128 Buy
SML2227 25mg $514 Buy
22204 1mg $34 Buy
22204 5mg $76 Buy
22204 25 mg $253 Buy

(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Chemical Properties,Uses,Production

Uses

Emricasan is an irreversible pan-caspase inhibitor that hinders caspase-mediated apoptosis and inflammation.?In addition, Emricasan may reduce hepatic injury and liver fibrosis.

Biological Activity

Emricasan is an antiapoptotic pan-caspase inhibitor. It has been in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) with advanced fibrosis (scarring) and cirrhosis. Emricasan has also been shown to protect infected astrocytes from ZIKV-induced cell death.', 'Emricasan, formerly known as IDN-6556, in combination with birinapan is used to tre at acute myeloid leukemia (AML). This small molecule irreversible inhibitor is under clinical investigation to reduce hepatic injury and liver fibrosis.

in vivo

Emricasan (PF 03491390; IDN-6556) is orally active that is retained in the liver for a prolonged period of time. TUNEL-positive cells are considerably increased by five-fold in mice fed a HFD and are reduced under Emricasan treatment. In accordance with this observation caspase-3 and -8 are increased in HFD-fed mice by 1.5- and 1.3-fold respectively and are significantly decreased by Emricasan treatment[2].
When comparing efficacy by multiple routes of administration, Emricasan is administered i.p., p.o., i.m., or i.v. (0.03-3 mg/kg). Caspase 3-like activities, measured as DEVD-AMC cleavage, dose dependently decreased with a 92.5% reduction after the highest dose of Emricasan (3 mg/kg). Emricasan is initially tested in the α-Fas model of liver injury, marked hepatocellular apoptosis, and peak ALT activities within 6 h. Emricasan is administered i.p. immediately after administration of α-Fas, ALT activities, measured 6 h later, decreased in a dose-dependent manner with an ED50 value of 0.08 (0.06-0.12) mg/kg[3].
Emricasan is a highly selective pan-caspase inhibitor demonstrating irreversible inhibition and a significant first-pass effect. In both syngeneic mouse islets and human islets transplanted into immunodeficient mice, Emricasan (i.p., 20 mg/kg) given for 7 days post-transplant led to a significantly enhanced rate of diabetes reversal as compared to vehicle[4].

IC 50

Caspase

storage

Store at -20°C

(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 143)Suppliers
Supplier Tel Email Country ProdList Advantage
Adachibio Inc. 		+81-8027837258 sales@adachi-bio.com Japan 992 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21628 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29856 58
TianYuan Pharmaceutical CO.,LTD 		+86-755-23284190 13684996853 sales@tianpharm.com CHINA 304 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12197 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58

View Lastest Price from (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Emricasan pictures 2025-05-07 Emricasan
254750-02-2
 US $37.00-87.00 / mg 98.69% 10g TargetMol Chemicals Inc.
(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid USP/EP/BP pictures 2021-08-18 (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid USP/EP/BP
254750-02-2
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
(S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid pictures 2019-07-06 (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid
254750-02-2
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • Emricasan pictures
  • Emricasan
    254750-02-2
  • US $37.00-87.00 / mg
  • 98.69%
  • TargetMol Chemicals Inc.

254750-02-2((S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid)Related Search:

PF 03491390 IDN 6556 (3S)-3-[(N-{[(2-tert-butylphenyl)amino](oxo)acetyl}-L-alanyl)amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (S)-3-((S)-2-(2-(2-tert-butylphenylaMino)-2-oxoacetaMido)propana N-[2-(tert-butyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide (S)-3-((S)-2-(2-((2-(tert-Butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetraf EMricasan (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid Emricasan, (IDN-6556 (S)-3-((S)-2-(2-((2-(tert-Butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tet Emricasan(IDN6556,PF03491390) (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid CS-1040 Emricasan, PF 03491390 CS-2634 IDN 6556; PF 03491390; PF03491390; PF-03491390; IDN-6556;IDN6556;PF03491390 IDN-6556;PF-03491390;PF03491390 L-Alaninamide, N-[2-(1,1-dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]- (S)-3-((S)-2-(2-(2-tert-butylphenylamino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid USP/EP/BP abs816139 N-[2-(1,1-Dimethylethyl)phenyl]-2-oxoglycyl-N-[(1S)-1-(carboxymethyl)-2-oxo-3-(2,3,5,6-tetrafluorophenoxy)propyl]-L-alaninamide EMricasan (3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (S) -3- (((S) -2- (2- (t-butylphenyl) amino) -2-oxoacetamido) propionamido) -4-oxo-5- (2,3,5,6-tetrafluorophenoxy) valeric acid Emricasan, 10 mM in DMSO 254750-02-2 C26H27F4N3O7 C26H27F4NO7