ChemicalBook >> CAS DataBase List >>JAK3-IN-6
JAK3-IN-6
- CAS No.
- 1443235-95-7
- Chemical Name:
- JAK3-IN-6
- Synonyms
- JAK3-IN-2;JAK3-IN-6;JAK3 inhibitor 6;JAK3-IN-6 (Compound 2);SelectiveJAK3inhibitor1;JAK3-IN-6, 10 mM in DMSO;JAK3-IN-2 (JAK3 inhibitor 2);inhibit,JAK3 IN 6,JAK,Inhibitor,JAK3IN6,JAK-3-IN-6,Janus kinase;Ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate;ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
- CBNumber:
- CB04813521
- Molecular Formula:
- C19H18N4O3
- Molecular Weight:
- 350.37
- MDL Number:
- MFCD31692331
- MOL File:
- 1443235-95-7.mol
Last updated:2024-11-19 23:02:33
JAK3-IN-6 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0022365 | JAK3-IN-6 98.07% | 1443235-95-7 | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0022365 | JAK3-IN-6 98.07% | 1443235-95-7 | 10mg | $155 | 2021-12-16 | Buy |
| ChemScene | CS-0022365 | JAK3-IN-6 98.07% | 1443235-95-7 | 50mg | $465 | 2021-12-16 | Buy |
| DC Chemicals | DC21158 | JAK3-IN-2 >98% | 1443235-95-7 | 250mg | $1100 | 2021-12-16 | Buy |
| DC Chemicals | DC21158 | JAK3-IN-2 >98% | 1443235-95-7 | 1g | $2200 | 2021-12-16 | Buy |
JAK3-IN-6 Chemical Properties,Uses,Production
Biological Activity
JAK3-IN-6 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM and 740 nM for JAK3, JAK1 and JAK2, respectively. It is more selective for JAK3 than BMX, EGFR, ITK and BTK.
in vitro
JAK3-IN-6 is a potent JAK3 inhibitor with IC50 of 0.15 nM, with 4300-fold selectivity for JAK3 over JAK1 in enzymatic activity assays, erythropoietin and 67-fold and 140-fold higher selectivity for granulocyte-macrophage colony-stimulating factor.
in vivo
JAK3-IN-6 completely inhibits the progression of inflammatory responses.
target
| Target | Value |
| JAK3 (Cell-free assay) | 0.07 nM(Ki) |
| JAK1 (Cell-free assay) | 320 nM(Ki) |
| JAK2 (Cell-free assay) | 740 nM(Ki) |
Synthesis of JAK3-IN-6 from 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-(3-aminophenyl)-, ethyl ester and Methacryloyl chloride
JAK3-IN-6 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 53)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30236 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
1443235-95-7(JAK3-IN-6)Related Search:
JAK3-IN-6
SelectiveJAK3inhibitor1
ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
JAK3-IN-2
(JAK3 inhibitor 2)
JAK3-IN-2
JAK3 inhibitor 6
7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-[3-[(2-methyl-1-oxo-2-propen-1-yl)amino]phenyl]-, ethyl ester
JAK3-IN-6 (Compound 2)
inhibit,JAK3 IN 6,JAK,Inhibitor,JAK3IN6,JAK-3-IN-6,Janus kinase
Ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
JAK3-IN-6, 10 mM in DMSO
1443235-95-7