Sulfo DBCO-PEG4-amine
- CAS No.
- 2055198-05-3
- Chemical Name:
- Sulfo DBCO-PEG4-amine
- Synonyms
- Sulfo DBCO-PEG4-NH2;12,15,18,21-Tetraoxa-4,8-diazatricosane-6-sulfonic acid, 23-amino-1-(11,12-dihydrodibenz[b,f]azocin-5(6H)-yl)-1,5,9-trioxo-
- CBNumber:
- CB03363995
- Molecular Formula:
- C32H42N4O10S
- Molecular Weight:
- 674.77
- MDL Number:
- MFCD30458045
- MOL File:
- 2055198-05-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Sulfo DBCO-PEG4-amine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-23310 | SulfoDBCO-PEG4-amine 95% | 2055198-05-3 | 25mg | $195 | 2021-12-16 | Buy |
| BroadPharm | BP-23310 | SulfoDBCO-PEG4-amine 95% | 2055198-05-3 | 100mg | $495 | 2021-12-16 | Buy |
| Iris Biotech GmbH | RL-2421 | DBCO-Sulfo-PEG(4)-NH2 | 2055198-05-3 | 100mg | $810 | 2021-12-16 | Buy |
| Iris Biotech GmbH | RL-2421 | DBCO-Sulfo-PEG(4)-NH2 | 2055198-05-3 | 500mg | $2565 | 2021-12-16 | Buy |
Sulfo DBCO-PEG4-amine Chemical Properties,Uses,Production
Description
Sulfo DBCO-PEG4-Amine is a water-soluble carboxyl-reactive building block with extended PEG spacer arm. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. The hydrophilic sulfonated spacer arm greatly improves water solubility of DBCO derivatized molecules and a provides a long and flexible connection. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
Sulfo DBCO-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Sulfo DBCO-PEG4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
Sulfo DBCO-PEG4-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32265 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6355 | 58 | |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 029-86217788 13892832556 | 2440688701@qq.com | China | 1986 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 55017 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85563444 18351873721 | purchase@synzest.com | China | 10434 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 10000 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2990 | 58 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80514535 19917294565 | et@chemextension.com | China | 5061 | 58 |