成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook >> CAS DataBase List >>GAMMA-SECRETASE INHIBITOR XII

GAMMA-SECRETASE INHIBITOR XII

CAS No.
161710-10-7
Chemical Name:
GAMMA-SECRETASE INHIBITOR XII
Synonyms
GSI-XII);Z-IL-CHO;Z-ILE-LEU-ALDEHYDE;γ-Secretase inhibitor XII;Z-Ile-Leu-aldehyde(Z-IL-CHO;GAMMA-SECRETASE INHIBITOR XII;γ-Secretase inhibitor XII (GSI-XII);Z-ILE-LEU-ALDEHYDE(Z-IL-CHO; GSI-XII);Z-IL-CHO;GSI-XII;Γ-SECRETASE INHIBITOR XII;Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
CBNumber:
CB0336194
Molecular Formula:
C20H30N2O4
Molecular Weight:
362.46
MDL Number:
MFCD04974201
MOL File:
161710-10-7.mol
Last updated:2024-10-28 23:16:16

GAMMA-SECRETASE INHIBITOR XII Properties

Boiling point 545.6±45.0 °C(Predicted)
Density 1.074±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥10.8 mg/mL in DMSO
form solid
pka 11.14±0.46(Predicted)
color White to off-white

GAMMA-SECRETASE INHIBITOR XII price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology B4908 Z-Ile-Leu-aldehyde 161710-10-7 5mg $333 2021-12-16 Buy
ApexBio Technology B4908 Z-Ile-Leu-aldehyde 161710-10-7 10mM(in 1mL DMSO) $390 2021-12-16 Buy
ChemScene CS-3642 Z-Ile-Leu-aldehyde ≥98.0% 161710-10-7 5mg $420 2021-12-16 Buy
ChemScene CS-3642 Z-Ile-Leu-aldehyde ≥98.0% 161710-10-7 10mg $600 2021-12-16 Buy
Biorbyt Ltd orb611572 Z-Ile-Leu-aldehyde 161710-10-7 100mg $1654.1 2021-12-16 Buy
Product number Packaging Price Buy
B4908 5mg $333 Buy
B4908 10mM(in 1mL DMSO) $390 Buy
CS-3642 5mg $420 Buy
CS-3642 10mg $600 Buy
orb611572 100mg $1654.1 Buy

GAMMA-SECRETASE INHIBITOR XII Chemical Properties,Uses,Production

Biological Activity

z-ile-leu-aldehyde (gamma-secretase inhibitor xii /gsi xii, z-il-cho) is a potent gamma-secretase inhibitor and notch signaling inhibitor.notch signaling impinges on many cellular processes, including cell proliferation, differentiation, apoptosis, and maintenance of stem cells. it is also involved in many developmental systems, including neurogenesis, angiogenesis, hematopoiesis, and myogenesis. deregulation of notch signaling leads to developmental syndromes and cancer [3]. in order to transmit a signal, notch receptors undergo a series of proteolytic cleavages after binding their cognate ligands of the delta-like and jagged family. γ-secretase is a large protease complex that cleaves the membrane-bound form of notch and releases the intracellular domain of the notch receptor. this step in notch signaling is pivotal in the activation of this signaling cascade [1] [2].ex vivo: a model of 3d culture of human breast cancer tissues was developed to study a series of 30 consecutive primary tumors from patients with untreated breast cancer for their sensitivity to the notch inhibitor gsi xii (15 μm). the results indicated that 24 tumors are sensitive to apoptosis induction by gsixii.

in vitro

gsi xii (10~15 μm) blocked the notch signaling, reduced cell viability and induced apoptosis in mopc315.bm murine multiple myeloma cells in vitro. gsi xii (10 μm) impaired murine osteoclast differentiation of receptor activator of nf-κb ligand (rankl)-stimulated raw264.7 murine monocyte/macrophage cell line [1]. gsi xii (8 μm ~ 15 μm) potently triggered an apoptotic response through inhibition of notch activity in the breast cancer cells. gsi xii also targets mammary cancer stem-like cells because it dramatically prevented in vitro mammosphere formation [3].

in vivo

notch inhibition through gsi xii (intraperitoneal injection, 10 mg/kg) reduced myeloma-specific paraprotein levels, bone loss and diminished osteolytic lesions in the mopc315.bm mice model[1]. notch inhibition using gsi xii (intraperitoneal injection, 5 mg/kg) blocked embryonal rhabdomyosarcoma tumorigenesis in mice[2].

References

[1]. schwarzer r, nickel n, godau j, et al. notch pathway inhibition controls myeloma bone disease in the murine mopc315. bm model[j]. blood cancer journal, 2014, 4(6): e217.
[2]. belyea b c, naini s, bentley r c, et al. inhibition of the notch-hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis[j]. clinical cancer research, 2011, 17(23): 7324-7336.
[3]. séveno c, loussouarn d, bréchet s, et al. γ-secretase inhibition promotes cell death, noxa upregulation, and sensitization to bh3 mimetic abt-737 in human breast cancer cells[j]. breast cancer research, 2012, 14(3): r96.

GAMMA-SECRETASE INHIBITOR XII Preparation Products And Raw materials

Raw materials

Preparation Products

GAMMA-SECRETASE INHIBITOR XII Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 31991 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38460 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd
+8617531972939 anna@api-made.com China 2943 58
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42958 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15402 60
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61

View Lastest Price from GAMMA-SECRETASE INHIBITOR XII manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-Ile-Leu-aldehyde pictures 2024-10-28 Z-Ile-Leu-aldehyde
161710-10-7
US $267.00 / mg 10g TargetMol Chemicals Inc.

GAMMA-SECRETASE INHIBITOR XII Spectrum

Z-ILE-LEU-ALDEHYDE Z-IL-CHO GAMMA-SECRETASE INHIBITOR XII Carbamic acid, N-[(1S,2S)-1-[[[(1S)-1-formyl-3-methylbutyl]amino]carbonyl]-2-methylbutyl]-, phenylmethyl ester Benzyl ((2S,3S)-3-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate Z-IL-CHO;GSI-XII;Γ-SECRETASE INHIBITOR XII Z-ILE-LEU-ALDEHYDE(Z-IL-CHO; GSI-XII) Z-Ile-Leu-aldehyde(Z-IL-CHO GSI-XII) γ-Secretase inhibitor XII (GSI-XII) γ-Secretase inhibitor XII 161710-10-7