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ChemicalBook >> CAS DataBase List >>BFH772

BFH772

CAS No.
890128-81-1
Chemical Name:
BFH772
Synonyms
BFH772;CS-2412;Bfh-722;BFH-772; BFH 772;6-((6-(Hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide;inhibit,BFH 772,VEGFR,BFH-772,BFH772,Vascular endothelial growth factor receptor,Inhibitor;1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-
CBNumber:
CB03147777
Molecular Formula:
C23H16F3N3O3
Molecular Weight:
439.39
MDL Number:
MFCD30534392
MOL File:
890128-81-1.mol
Last updated:2024-10-30 20:13:01

BFH772 Properties

Boiling point 541.2±50.0 °C(Predicted)
Density 1.432±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form A crystalline solid
pka 12.65±0.70(Predicted)
color White to off-white
FDA UNII T1IV236CVP

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

BFH772 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21386 BFH-772 890128-81-1 1mg $38 2024-03-01 Buy
Cayman Chemical 21386 BFH-772 890128-81-1 5mg $166 2024-03-01 Buy
Cayman Chemical 21386 BFH-772 890128-81-1 10mg $292 2024-03-01 Buy
Cayman Chemical 21386 BFH-772 890128-81-1 25mg $593 2024-03-01 Buy
ApexBio Technology B6199 BFH772 890128-81-1 50mg $709 2021-12-16 Buy
Product number Packaging Price Buy
21386 1mg $38 Buy
21386 5mg $166 Buy
21386 10mg $292 Buy
21386 25mg $593 Buy
B6199 50mg $709 Buy

BFH772 Chemical Properties,Uses,Production

Description

BFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor). It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.

in vitro

bfh772 was highly effective at targeting vegfr2 kinase, however, lost 500-fold potency on flk-1, flt-1, and flt-4. bfh772 also targeted b-raf, ret, and tie-2, albeit with at least 40-fold lower potency. bfh772 inhibited the ligand induced autophosphorylation of ret, pdgfr, and kit kinases. bfh772 was selective against the kinases of egfr, erbb2, ins-r, and igf-1r and against the cytoplasmic bcr-abl kinase [1].

in vivo

the dose response curves of bfh772 at 0.3, 1, and 3 mg/kg showed that even at the lowest concentrations, this naphthalene-1-carboxamide inhibited vegf induced tissue weight and tie-2 levels but only reached statistical significance at 1 mg/kg and above. moreover, bfh772 at 3 mg/kg orally dosed once per day could potently inhibit melanoma growth (54-90% for primary tumor and 71-96% for metastasis tumor) when compared with control ratios [1].

IC 50

3 nm

References

[1] bold g, et al. a novel potent oral series of vegfr2 inhibitors abrogate tumor growth by inhibiting angiogenesis. j med chem. 2016 jan 14;59(1):132-46.
[2] http://adisinsight. springer.com/trials/700244037

BFH772 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32002 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38460 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58

View Lastest Price from BFH772 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BFH772 pictures 2024-10-30 BFH772
890128-81-1
US $38.00-105.00 / mg 99.36% 10g TargetMol Chemicals Inc.
BFH772 pictures 2019-12-23 BFH772
890128-81-1
US $1.00 / g 1g 99.99% 200kg Career Henan Chemical Co
  • BFH772 pictures
  • BFH772
    890128-81-1
  • US $38.00-105.00 / mg
  • 99.36%
  • TargetMol Chemicals Inc.
  • BFH772 pictures
  • BFH772
    890128-81-1
  • US $1.00 / g
  • 99.99%
  • Career Henan Chemical Co
BFH772 Bfh-722 CS-2412 BFH-772; BFH 772 1-Naphthalenecarboxamide, 6-[[6-(hydroxymethyl)-4-pyrimidinyl]oxy]-N-[3-(trifluoromethyl)phenyl]- 6-((6-(Hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide inhibit,BFH 772,VEGFR,BFH-772,BFH772,Vascular endothelial growth factor receptor,Inhibitor 890128-81-1