Vardenafil hydrochloride trihydrate
- CAS No.
- 330808-88-3
- Chemical Name:
- Vardenafil hydrochloride trihydrate
- Synonyms
- VARDENAFIL HYDROCHLORIDE TRIHYDRATE;Vardenafil hydrochloride CRS;Vardenafil for system suitability;Vardenafil Hydrochloride (1711010);vardenafil hydrochloride trihyrate;Verdenafil Hydrochloride Trihydrate;2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride hydrate;2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one hydrochloride trihydrate;2-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one,hydrochloride, hydrate (1:1:3);IMidazo[5,1-f][1,2,4]triazin-4(1H)-one,2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-Methyl-7-propyl-,hydrochloride, hydrate (1:1:3)
- CBNumber:
- CB01230855
- Molecular Formula:
- C23H35ClN6O5S
- Molecular Weight:
- 543.08
- MDL Number:
- MFCD08458876
- MOL File:
- 330808-88-3.mol
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| solubility | ≥13.3 mg/mL in DMSO; ≥3.42 mg/mL in EtOH with gentle warming and ultrasonic; ≥95 mg/mL in H2O |
| form | Solid |
| color | White to off-white |
| FDA UNII | 5M8S2CU0TS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H373 | |||||||||
| Precautionary statements | P260-P264-P270-P301+P310-P314-P405 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| HS Code | 2933595960 | |||||||||
| NFPA 704 |
|
Vardenafil hydrochloride trihydrate price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001647 | Vardenafil hydrochloride trihydrate European Pharmacopoeia (EP) Reference Standard | 330808-88-3 | y0001647 | $153 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR2720 | Vardenafil Hydrochloride certified reference material, pharmaceutical secondary standard | 330808-88-3 | 500MG | $253 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1711010 | Vardenafil for system suitability | 330808-88-3 | 200mg | $429 | 2024-03-01 | Buy |
| Cayman Chemical | 14930 | Vardenafil (hydrochloride hydrate) ≥98% | 330808-88-3 | 10mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 14930 | Vardenafil (hydrochloride hydrate) ≥98% | 330808-88-3 | 25mg | $222 | 2024-03-01 | Buy |
Vardenafil hydrochloride trihydrate Chemical Properties,Uses,Production
Description
Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM). It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment. Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior. Formulations containing vardenafil have been used in the treatment of erectile dysfunction.
Uses
Vardenafil Hydrochloride Trihydrate (cas# 330808-88-3) has therapeutic applications and used in cosmetics and personal care products.
Uses
Vardenafil hydrochloride trihydrate is a potent inhibitor of PDE5 (IC50 = 0.2-1.2 nM) that less effectively blocks the activities of PDE6, PDE1, and PDE11 (IC50s = 2, 230, and 130 nM, respectively). PDE5 inhibitors, including vardenafil, have applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.[Cayman Chemical]
Biological Activity
Vardenafil HCl Trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
in vitro
Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). Vardenafil significantly enhances the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiates both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil (100 mM) increases cyclic GMP levels in rat hippocampal slices. Vardenafil, tadalafil, and Sildenafil each competitively inhibit cGMP hydrolysis by phosphodiesterase-5 (PDE5), thereby fostering cGMP accumulation and relaxation of vascular smooth muscle.
in vivo
Vardenafil dose-dependently potentiates erectile responses to intravenously administered sodium nitroprusside in rabbit. Vardenafil (3 mg/kg, p.o.) results in an improved object discrimination performance in rats. Vardenafil (30 mg/L, p.o.) increases both iNOS and proliferating cell nuclear antigen expression (SM cell replication) in rats, with normalization of the dynamic infusion cavernosometry drop rate and SM/collagen ratio.Vardenafil induces powerful preconditioning-like cardioprotective effect against ischemia/reperfusion injury through opening of mitochondrial K(ATP) channels in the heart of rabbit. Vardenafil protects the ischemic myocardium against reperfusion injury through a mechanism dependent on mitochondrial K(ATP) channel opening.
References
[1] saenz de tejada i1, angulo j, cuevas p, fernández a, moncada i, allona a, lledó e, körschen hg, niewöhner u, haning h, pages e, bischoff e.the phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new pde5 inhibitor vardenafil. int j impot res. 2001 oct;13(5):282-90.
Vardenafil hydrochloride trihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2524 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32002 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9315 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38460 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
View Lastest Price from Vardenafil hydrochloride trihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-30 | Vardenafil hydrochloride trihydrate
330808-88-3
|
US $38.00-118.00 / mg | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2021-07-13 | VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)
330808-88-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)
330808-88-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Vardenafil hydrochloride trihydrate
330808-88-3
- US $38.00-118.00 / mg
- 99.89%
- TargetMol Chemicals Inc.
-
- VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)
330808-88-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE)
330808-88-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd