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NS8593 HYDROCHLORIDE

NS8593 HYDROCHLORIDE Struktur
875755-24-1
CAS-Nr.
875755-24-1
Englisch Name:
NS8593 HYDROCHLORIDE
Synonyma:
NS8593;NS8593 HCl;NS8593 HYDROCHLORIDE;N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;: N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride;NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel
CBNumber:
CB8973069
Summenformel:
C17H17N3.ClH
Molgewicht:
299.803
MOL-Datei:
875755-24-1.mol

NS8593 HYDROCHLORIDE Eigenschaften

storage temp. 
2-8°C
L?slichkeit
DMSO: >10mg/mL
Aggregatzustand
powder
Farbe
White to off-white
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H413 Kann für Wasserorganismen sch?dlich sein, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 4
Sicherheit

NS8593 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (KCa2/SK) channels (Kds = 0.42, 0.6, and 0.73 μM for KCa2.1/SK1, KCa2.2/SK2, and KCa2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for KCa2/SK channels over intermediate- (KCa3.1/IKCa1) and large-conductance (BK) potassium channels at 10 μM. NS 8593 induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC50s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC50s = 16.4 and 32.2 μM, respectively). It inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at a dose of 500 μM. NS 8593 (5 mg/kg) decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats.

Verwenden

NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells).

Biochem/physiol Actions

The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.

NS8593 HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


NS8593 HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 39)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581
sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
sales@rechemscience.com China 2988 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266
China 4566 55
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720
lucy@atkchemical.com China 9952 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6777 58

  • NS8593 HYDROCHLORIDE
  • : N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride
  • NS8593
  • N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine
  • NS8593 HCl
  • NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel
  • 875755-24-1
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