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3'-fluoro-3'-deoxyadenosine

3'-fluoro-3'-deoxyadenosine Struktur
75059-22-2
CAS-Nr.
75059-22-2
Englisch Name:
3'-fluoro-3'-deoxyadenosine
Synonyma:
3'-F-3'-rA;3'-fluoro-3'-deoxyadenosine;3’-Deoxy-3’-fluoro adenosine;Adenosine, 3'-deoxy-3'-fluoro-;(2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol
CBNumber:
CB61333211
Summenformel:
C10H12FN5O3
Molgewicht:
269.23
MOL-Datei:
75059-22-2.mol

3'-fluoro-3'-deoxyadenosine Eigenschaften

Schmelzpunkt:
211-212 °C
Siedepunkt:
628.6±65.0 °C(Predicted)
Dichte
2.01±0.1 g/cm3(Predicted)
pka
12.45±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChI
InChI=1S/C10H12FN5O3/c11-5-4(1-17)19-10(7(5)18)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1
InChIKey
QCDAWXDDXYQEJJ-QYYRPYCUSA-N
SMILES
OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1F

Sicherheit

3'-fluoro-3'-deoxyadenosine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

3'-deoxy-3'-fluoroadenosine can be used as pharmaceutical intermediates for pharmaceutical experimental research.

Biologische Aktivit?t

3'-Fluoro-3'-deoxyadenosine was active against a broad range of viruses, encompassing both DNA viruses [pox (vaccinia)], single-stranded (+) RNA viruses [picorna (polio, Coxsackie B), toga (sindbis, Semliki Forest)] and double-stranded RNA viruses (reo). Its antiviral activity spectrum, 3'-fluoro-3'-deoxyadenosine, clearly differed from those adenosine analogs known as inhibitors of S-adenosylhomocysteine hydrolase. 3'-Fluoro-3'-deoxyadenosine also proved effective in vivo in inhibiting tail lesion formation in mice inoculated intravenously with vaccinia virus[1].

3'-fluoro-3'-deoxyadenosine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

β-D-Xylofuranoside, methyl 3,5-O-(1-methylethylidene)-

Downstream Produkte

3'-Deoxy-3'-fluoro-N6-benzoyladenosine

3'-fluoro-3'-deoxyadenosine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 3'-fluoro-3'-deoxyadenosine
  • (2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol
  • 3'-F-3'-rA
  • Adenosine, 3'-deoxy-3'-fluoro-
  • 3’-Deoxy-3’-fluoro adenosine
  • 75059-22-2
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