9,10-Secocholesta-5,7,10(19)-trien-3-ol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R48/25:Giftig: Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White or colorless crystalline solid. Odorless;
Verwenden
Vitamin D3 analogue.
Indications
Vitamin D is the collective term for a group of compounds
formed by the action of ultraviolet irradiation on
sterols. Cholecalciferol (vitamin D
3) and calciferol (vitamin
D
2) are formed by irradiation of the provitamins 7-
dehydrocholesterol and ergosterol, respectively. The
conversion to vitamin D3 occurs in the skin. The liver is
the principal storage site for vitamin D, and it is here that
the vitamin is hydroxylated to form 25-hydroxyvitamin
D. Additional hydroxylation to form 1,25-dihydroxyvitamin
D occurs in the kidney in response to the need for
calcium and phosphate
Definition
A free vitamin D
3, isolated in crystalline state from
the 3,5-dinitrobenzoate, produced by irradiation,
and equivalent in activity to vitamin D3 of tunaliver oil.
Allgemeine Beschreibung
Fine colorless crystals. Water insoluble.
Air & Water Reaktionen
Sensitive to moisture, air and light. . Water insoluble.
Reaktivit?t anzeigen
Vitamin D3 may react vigorously with strong oxidizing agents. May react exothermically with reducing agents to release hydrogen gas.
Health Hazard
SYMPTOMS: Symptoms of exposure to Vitamin D3 may include weakness, fatigue, lassitude headache, nausea, vomiting, diarrhea, polyuria, polydipsia, nocturia, decrease urinary concentrating ability, proteinuria, tissue calcification, hypertension and osteoporosis.
Brandgefahr
Flash point data for Vitamin D3 are not available. Vitamin D3 is probably combustible.
Landwirtschaftliche Anwendung
Rodenticide: Used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body
levels of calcium and phosphorus, and in mineralization of
bone. Not approved for use in EU countries. Registered
for use in the U.S. and other countries.
Handelsname
DELSTEROL®; DEPARAL®; D3-
VIGANTOL®; QUINTOX®; RAMPAGE®; RICKETON®;
TRIVITAN®; VIGORSAN®; VITINC DAN-DEE-3®
Mechanism of action
1, 25-(OH)
2D
3 exerts its influence within target tissues
through high-affinity sterol-specific intracellular receptor
proteins.The D
3 receptor, similar to steroid receptor
systems, translocates the hormone from the cell cytoplasm
to the nucleus, where biological response is initiated
via transcription and translation.
Clinical Use
The principal disorder associated with inadequate
vitamin D intake is rickets. The low blood calcium and
phosphate levels that occur during vitamin D deficiency
stimulate parathyroid hormone secretion to restore calcium
levels. In children, this deficiency
leads to the formation of soft bones that become deformed
easily; in adults, osteomalacia results from the
removal of calcium from the bone.Vitamin D deficiency
may occur in patients with metabolic disorders, such as
hypoparathyroidism and renal osteodystrophy. The requirement
for vitamin D is slightly higher in members
of darker-pigmented races, since melanin interferes
with the irradiation that produces vitamin D
3 in the
skin. People with limited exposure to the sun may need
to supplement vitamin D intake.
Nebenwirkungen
The hypercalcemia resulting from hypervitaminosis
D is responsible for toxic symptoms such as muscle
weakness, bone pain, anorexia, ectopic calcification, hypertension,
and cardiac arrhythmias. Toxicity in infants
can result in mental and physical retardation, renal failure,
and death.
Sicherheitsprofil
Poison by ingestion. An
experimental teratogen. When heated to
decomposition it emits acrid smoke and
irritating fumes.
m?gliche Exposition
Sterol rodenticide used in bait for vermin control. Vitamin D is a steroid hormone that has an important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. Not approved for use in EU countries
Stoffwechselwegen
Cholecalciferol (vitamin D3) is the mammalian form of vitamin D. It is
normally produced in the skin by the action of UV light on its precursor, 7-
dehydrocholesterol. Essential amounts of the vitamin are obtained thus or
from dietary sources such as fish oils. The active form of the vitamin is
1,25-dihydroxy-cholecalciferol. Its formation occurs in two stages: 25-
hydroxylation in the liver, followed by 1-hydroxylation in the kidney (see
Engstrom and Koszewski, 1989 and references cited therein).
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required
l?uterung methode
It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 III 2811, 6 IV 4149.]
Inkompatibilit?ten
Sensitive to air, light, and moisture. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste disposal
Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
9,10-Secocholesta-5,7,10(19)-trien-3-ol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
