Cycloguanil Hydrochloride
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- CAS-Nr.
- 152-53-4
- Englisch Name:
- Cycloguanil Hydrochloride
- Synonyma:
- uaniL;BN 2410;oguaniL;NSC 3074;NSC 3074-d4;Chloroprimidine;Chloroguanide Triazine;Cycloguanil Hydrochloride;Cycloguanil-d4 Hydrochloride;Cycloguanidine hydrochloride
- CBNumber:
- CB51564793
- Summenformel:
- C11H14ClN5.ClH
- Molgewicht:
- 288.181
- MOL-Datei:
- 152-53-4.mol
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Cycloguanil Hydrochloride Eigenschaften
- Schmelzpunkt:
- 210-2150C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Cycloguanil Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR; K
is = 1.5 and 0.79 nM for the
P. falciparum and
P. berghei enzymes, respectively). It is active against ten
P. falciparum field isolates (IC
50s = 0.12-1,400 μg/ml). Cycloguanil reduces parasitemia in a mouse model of
P. berghei infection (ED
50 = 2 mg/kg). It also reduces parasitemia in a rhesus monkey model of
P. cynomolgi infection when administered at a dose of 0.3 mg/kg.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Labelled antimalarial drug
Cycloguanil Hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cycloguanil Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 69)Lieferanten
152-53-4()Verwandte Suche:
- 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
- BN 2410
- Chloroguanide Triazine Hydrochloride
- Cycloguanil Hydrochloride
- NSC 3074
- 1-(4-Chlorophenyl-d4)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine Hydrochloride
- Chloroguanide-d4 Triazine Hydrochloride
- Cycloguanil-d4 Hydrochloride
- NSC 3074-d4
- 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride
- 1-4-Chlorophenyl-1,6-dihydro-(6,6-dimethyl-d6)-1,3,5-triazine-2,4-diamine Nitrate
- 1,3,5-Triazine-2,4-diamine,1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, hydrochloride (1:1)
- Chloroguanide Triazine
- uaniL
- 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine,hydrochloride
- oguaniL
- Cycloguanil D6 HydrochlorideQ: What is
Cycloguanil D6 Hydrochloride Q: What is the CAS Number of
Cycloguanil D6 Hydrochloride Q: What is the storage condition of
Cycloguanil D6 Hydrochloride Q: What are the applications of
Cycloguanil D6 Hydrochloride
- Chloroprimidine
- Cycloguanidine hydrochloride
- Cycloguanil,Inhibitor,Parasite,Drug Metabolite,Cycloguanil hydrochloride,inhibit
- 152-53-4
- C11H11D4Cl2N5
- C11H15Cl2N5
- C11H14ClN5HCl
- Aromatics Compounds
- aromatics
- Bases & Related Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Nucleotides
- Pharmaceuticals
- Isotope Labeled Compounds
- Isotope Labelled Compounds
