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Amrinon

Amrinone Struktur
60719-84-8
CAS-Nr.
60719-84-8
Bezeichnung:
Amrinon
Englisch Name:
Amrinone
Synonyma:
inocor;AMRINONE;win40680;Cartonic;Vesistol;Wincoram;Imrinone;awd08-250;Amirinone;INAMRINONE
CBNumber:
CB3774164
Summenformel:
C10H9N3O
Molgewicht:
187.2
MOL-Datei:
60719-84-8.mol

Amrinon Eigenschaften

Schmelzpunkt:
294-297°C (dec.)
Siedepunkt:
321.94°C (rough estimate)
Dichte
1.2025 (rough estimate)
Brechungsindex
1.4830 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
L?slichkeit
DMF: 0.3 mg/ml; DMSO: 0.5 mg/ml
Aggregatzustand
Crystals
pka
12.05±0.10(Predicted)
Farbe
Crystals from DMF
Wasserl?slichkeit
Insoluble in water or chloroform. Slightly soluble in acetic acid or DMF. Soluble in DMSO
CAS Datenbank
60719-84-8(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T,Xn
R-S?tze: 25-36/37/38-20/21/22
S-S?tze: 28-45-36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. DW2500000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29333999
Toxizit?t LD50 orl-rat: 102 mg/kg NDADD8 1,259,83
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit

Amrinon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Amrinone is a positive inotropic agent useful in the management of severe congestive heart failure. It is effective even in unresponsive, fully digitalized patients.

Chemische Eigenschaften

Crystalline Solid

Verwenden

Amrinone is used for short-term treatment of cardiac insufficiency that does not respond to treatment of other drugs.

Allgemeine Beschreibung

During normal heart function, cAMP performsimportant roles in regulating intracellular calcium levels.That is, certain calcium channels and storage sites forcalcium must be activated by cAMP-dependant protein kinases.Because cAMP plays an indirect role in the contractilityprocess, agents that inhibit its degradation will providemore calcium for cardiac contraction. One phosphodiesteraseenzyme that is involved in the hydrolysis of myocardiumcAMP is F-III. Amrinone, 5-amino (3,4 -dipyridin)-6 1 (H)-one (Inocor), possesses positive isotropic effects as aresult of its ability to inhibit this phosphodiesterase. In 1999,the USP Nomenclature Committee and the United StatesAdopted Names (USAN) Council approved changing thenonproprietary name and the current official monograph titleof amrinone to inamrinone. This change in nomenclature wasa result of amrinone being confused with amiodarone becauseof the similarity of the names. This was reported to cause confusionbetween the products that led to medication errors,some of which resulted in serious injury or death.

Sicherheitsprofil

Poison by ingestion andintravenous routes. Human systemic effects by ingestion:cardiac arrhythmias, liver function, thrombocytopenia. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes o

Amrinon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Amrinon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 240)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29886 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 904 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58

60719-84-8(Amrinon)Verwandte Suche:


  • 5-AMINO-[3,4'-BIPYRIDIN]-6[1H]-ONE
  • awd08-250
  • cordemcura
  • win40680
  • 3-AMINO-5-(4-PYRIDINYL)-2(1H)-PYRIDINONE
  • AMRINONE
  • inocor
  • INAMRINONE
  • 5-AMINO-(3,4''-BIPYRIDIN)-6(1H)-ONE (AMRINONE)
  • Amrinone,Vesistol,Wincavam
  • 3-Amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone
  • 5-Amino-1,6-dihydro-6-oxo-[3,4'-bipyridine]
  • Cartonic
  • Vesistol
  • Wincoram
  • Amrinone (500 mg)
  • Amirinone
  • 4’-bipyridin)-6(1h)-one,5-amino-(
  • Imrinone
  • 3-Amino-5-(pyridin-4-yl)pyridin-2(1H)-one
  • [3,4'-Bipyridin]-6(1H)-one, 5-amino-
  • Amrinone USP/EP/BP
  • TIANFU-CHEM 60719-84-8 Amrinone
  • Amrinone (Inamrinone) (1034308)
  • 5-Amino-[3,4’-bipyridin]-6(1H)-one
  • 60719-84-8
  • C10H9N3O
  • Substrate Analogs
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Enzymes, Inhibitors, and Substrates
  • Biochemicals and Reagents
  • BioChemical
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  • ACYLPIRIN
  • Active Pharmaceutical Ingredients
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Calcium channel
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