Lithocholsure
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- CAS-Nr.
- 434-13-9
- Bezeichnung:
- Lithocholsure
- Englisch Name:
- LITHOCHOLIC ACID
- Synonyma:
- Lithocolic acid;NCI-C03861;Lithocholate;(R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;NCI-CO-3861;lithocholicaci;LITHOCHOLIC ACID;Lithocholic aCld;Stone cholic acid;Lithocholic Acide
- CBNumber:
- CB2342229
- Summenformel:
- C24H40O3
- Molgewicht:
- 376.57
- MOL-Datei:
- 434-13-9.mol
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Lithocholsure Eigenschaften
- Schmelzpunkt:
- 183-188 °C (lit.)
- alpha
- D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)
- Siedepunkt:
- 445.09°C (rough estimate)
- Dichte
- 1.0454 (rough estimate)
- Brechungsindex
- 35.5 ° (C=1, EtOH)
- Flammpunkt:
- 9℃
- storage temp.
- room temp
- L?slichkeit
- Chloroform (Slightly), Dichloromethane (Slightly, Heated), DMSO (Slightly, Heated)
- pka
- 4.76±0.10(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White to off-white
- Optische Aktivit?t
- +3220 (c 1.5, ethanol)
- Wasserl?slichkeit
- 18.83ug/L(25 ºC)
- Merck
- 5545
- BRN
- 3217757
- InChIKey
- SMEROWZSTRWXGI-HVATVPOCSA-N
- LogP
- 6.700 (est)
- CAS Datenbank
- 434-13-9(CAS DataBase Reference)
- EPA chemische Informationen
- Lithocholic acid (434-13-9)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P403+P233 |
An einem gut belüfteten Ort aufbewahren. Beh?lter dicht verschlossen halten. |
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Lithocholsure Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white powder
Verwenden
Lithocholic acid has been used in a study to assess cholestasis and its action on several organs and tissues in rats. It has also been used in a study to investigate the regulation of hepatic phospholipid and bile acid homeostasis through SMAD3 activation by TGFβ.
Definition
ChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Allgemeine Beschreibung
Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder.
Air & Water Reaktionen
Insoluble in water.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes.
Brandgefahr
Flash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible.
l?uterung methode
Lithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]
Lithocholsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lithocholsure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 388)Lieferanten
434-13-9(Lithocholsure)Verwandte Suche:
Cholsure
Ursodeoxycholsure
3-α,12-α-Dihydroxy-5-β-cholan-24-sure
5-Methyl-2-(1-methylethenyl)-cyclohexanol
(+)-Neomenthol
(1S-(1α,2β,5beta))-5-Methyl-(1-isopropyl)cyclohexan-2-ol
p-Menth-1-en-4-ol
Chenodesoxycholsure
(+)-Menthol
3-α-Hydroxy-7-oxo-5-β-cholan-24-sure
L-Menthol
Dinatrium-5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-yliden)-1,2-dihydro-3H-indol-3-on)disulfonat
3α,7α-Dihydroxy-12-oxo-5β-cholan-24-sure
Natriumcholat
Natriumdesoxycholat
Cholan-24-sure
Natrium-2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]ethan-1-sulfonat
3-α,6-α-Dihydroxy-5-β-cholan-24-sure
- 17-beta-(1-Methyl-3-carboxypropyl)ethiocholan-3-alpha-ol
- 17beta-(1-methyl-3-carboxypropyl)etiocholan-3alpha-ol
- BETA-CHOLANIC ACID-3-ALPHA-OL
- HYDROYCHOLANIC ACID
- 3-HYDROXYCHOLANIC ACID
- 3ALPHA-HYDROXYCHOLANIC ACID
- 3ALPHA-HYDROXY-5BETA-CHOLANIC ACID
- 3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID
- 5BETA-CHOLAN-24-OIC ACID-3A-OL
- 5BETA-CHOLAN-24-OIC ACID-3ALPHA-OL
- 5BETA-CHOLANIC ACID-3ALPHA-OL
- LITHOCHOLIC ACID
- 3α-Hydroxy-5β-cholan-24-oic acid
- 3α-Hydroxy-5β-cholanic acid
- 5β-Cholan-24-oic acid-3α-ol
- Lithocholic Acide
- Lithocholic acid,3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
- 17β-(1-Methyl-3-car-boxypropyl) etiocholan-3α-ol
- (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,]
- LITHOCHOLIC ACID(RG)
- 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol
- 3β-Hydroxyallocholanic acid
- NCI-CO-3861
- Lithocholic acid,98%
- Lithocholic acid3alpha-Hydroxycholanic acid
- Lithocholic acid, 98% 5GR
- (3α,5β)-3-Hydroxycholan-24-oic Acid
- 3α-Hydroxy-5β-cholan-24-oate
- 3α-Hydroxy-5β-cholanoic Acid
- 5beta-Cholanic Acid-3alpha-ol
3alpha-Hydroxy-5beta-cholanic Acid
- 3-alpha-hydroxy-5-beta-cholan-24-oicaci
- 3alpha-hydroxy-5beta-cholan-24-oicaci
- 3-alpha-hydroxy-5-beta-cholanicaci
- 3alpha-Hydroxy-5beta-cholanoic acid
- 3alpha-hydroxy-5beta-cholanoicacid
- 3-hydroxy-,(3-alpha,5-beta)-cholan-24-oicaci
- 3-hydroxy-,(3alpha,5beta)-cholan-24-oicaci
- 3-Hydroxycholan-24-oic acid
- 3-hydroxycholan-24-oicacid
- 5beta-Cholan-24-oic acid, 3alpha-hydroxy-
- 5-beta-Cholanic acid, 3-alpha-hydroxy-
- Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)-
- Cholan-24-oic acid, 3-hydroxy-, (3α,5β)-
- Lithocholic aCld
- LITHOCHOLIC ACID >=95%
- Ursodeoxycholic Acid Impurity 3（Ursodeoxycholic Acid EP Impurity C）
- Ursodeoxycholic Acid EP Impurity C
- Stone cholic acid
- Chenodeoxycholic Acid Impurity 3
- Lithocholic acid CRS
- LithocholicAcid>
- LITHOCHOLIC ACID USP/EP/BP
- Chenodeoxycholic acid EP Impurity C
- ALPHA-HYDROXY-5BETA-CHOLANIC ACID
- Chenodeoxycholic Acid EP Impurity C (Ursodeoxycholic Acid EP Impurity C/ Lithocholic Acid/ 7-Deoxy Ursodeoxycholic Acid/ 7-Deoxy Chenodeoxycholic Acid)
- Ursodeoxycholic Acid EP Impurity C (Lithocholic Acid/ Chenodeoxycholic Acid EP Impurity B/ 7-Deoxy Ursodeoxycholic Acid/ 7-Deoxy Chenodeoxycholic Acid)
- Ursodeoxycholic Acid EP Impurity C 434-13-9
- LITHOCHOLIC ACID,434-13-9
