GSK840
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- CAS號(hào):
- 2361146-30-5
- 英文名:
- GSK840
- 英文別名:
- GSK840;tert-butyl2-(4-(5-(methylcarbamoyl)-1H-benzo[d]im;tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate;Inhibitor,RIP kinase,GSK 840,Receptor-interacting protein kinases,GSK840,inhibit,GSK-840,RIPK;Benzeneacetic acid, 4-[5-[(methylamino)carbonyl]-1H-benzimidazol-1-yl]-, 1,1-dimethylethyl ester
- 中文名:
- GSK840
- 中文別名:
- 化合物GSK840;化合物 T11501;2-(4-(5-(甲基氨基甲酰基)-1H-苯并[D]咪唑-1-基)苯基)乙酸叔丁酯
- CBNumber:
- CB95419747
- 分子式:
- C21H23N3O3
- 分子量:
- 365.43
- MOL File:
- 2361146-30-5.mol
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GSK840化學(xué)性質(zhì)
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密度:
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1.18±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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110 mg/mL in DMSO
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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14.16±0.46(Predicted)
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顏色:
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Light yellow to yellow
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GSK840性質(zhì)、用途與生產(chǎn)工藝
GSK840 (GSK'840) 是一種受體相互作用蛋白激酶 3 (RIP3 或 RIPK3) 抑制劑，高親和力結(jié)合 RIP3 激酶結(jié)構(gòu)域，IC50 值為 0.9 nM，并抑制激酶活性，IC50 值為 0.3 nM。
GSK840 (GSK'840) (0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner.
GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors.
Cell Viability Assay
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Cell Line:
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Human HT-29 cells (TNF 10 ng/ml + zVAD-fmk 20 μM + SMAC007 100 nM)
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Concentration:
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0.01-3 μM
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Incubation Time:
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24 hours
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Result:
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Blocked TNF-induced necroptosis in a concentration-dependent manner.
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GSK840
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-104021 | GSK840
GSK840 | 2361146-30-5 | 5mg | 720元 |
| 2024/11/08 | HY-104021 | GSK840
GSK840 | 2361146-30-5 | 10mM * 1mLin DMSO | 792元 |
2361146-30-5, GSK840 相關(guān)搜索:
- 抑制劑
- 2-(4-(5-(甲基氨基甲?；?-1H-苯并[D]咪唑-1-基)苯基)乙酸叔丁酯
- 化合物GSK840
- 化合物 T11501
- 2361146-30-5
- Benzeneacetic acid, 4-[5-[(methylamino)carbonyl]-1H-benzimidazol-1-yl]-, 1,1-dimethylethyl ester
- tert-butyl2-(4-(5-(methylcarbamoyl)-1H-benzo[d]im
- Inhibitor,RIP kinase,GSK 840,Receptor-interacting protein kinases,GSK840,inhibit,GSK-840,RIPK
- tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate
- GSK840