200803-37-8
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- CAS號(hào):
- 200803-37-8
- 英文名:
- OSIP-486823
- 英文別名:
- CP248;OSIP-486823;OSIP486823,OSIP 486823;1H-Indene-3-acetamide, 5-fluoro-2-methyl-N-(phenylmethyl)-1-[(3,4,5-trimethoxyphenyl)methylene]-, (1Z)-
- 中文名:
- 200803-37-8
- 中文別名:
- 化合物 T13807;化合物 OSIP-486823
- CBNumber:
- CB93175568
- 分子式:
- C29H28FNO4
- 分子量:
- 473.54
- MOL File:
- 200803-37-8.mol
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200803-37-8化學(xué)性質(zhì)
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沸點(diǎn):
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667.3±55.0 °C(Predicted)
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密度:
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1.206±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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15.72±0.46(Predicted)
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顏色:
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Light yellow to yellow
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200803-37-8性質(zhì)、用途與生產(chǎn)工藝
OSIP-486823 是一種新型的微管干擾劑，對(duì)蛋白激酶 G (PKG) 和微管均具有生物學(xué)作用。
OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC
50
of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells.
200803-37-8
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2025/02/08 | HY-U00004 | OSIP-486823 | 200803-37-8 | 1 mg | 5800元 |
| 2023/03/20 | HY-U00004 | 200803-37-8
OSIP-486823 | 200803-37-8 | 5mg | 14500元 |
200803-37-8, 200803-37-8 相關(guān)搜索:
- 抑制劑
- 化合物 OSIP-486823
- 化合物 T13807
- 200803-37-8
- OSIP486823,OSIP 486823
- 1H-Indene-3-acetamide, 5-fluoro-2-methyl-N-(phenylmethyl)-1-[(3,4,5-trimethoxyphenyl)methylene]-, (1Z)-
- CP248
- OSIP-486823