2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽
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- CAS號:
- 1049741-55-0
- 英文名:
- 4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE
- 英文別名:
- Cardiogen (Myocardium);CARDIOGENOL C HYDROCHLORIDE;Cardiogenol C hydrochloride(b);Cardiogenol C hydrochloride, 10 mM in DMSO;2-[[2-[(4-Methoxyphenyl)aMino]-4-pyriMidinyl]aMino]ethanol Hydrochloride;4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE;2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol hydrochloride (1:1);Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1)
- 中文名:
- 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽
- 中文別名:
- 心源醇C 鹽酸鹽;化合物 CARDIOGENOL C HYDROCHLORIDE;2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽;化合物CARDIOGENOL C HYDROCHLORIDE,10 MM DMSO 溶液
- CBNumber:
- CB8668084
- 分子式:
- C13H17ClN4O2
- 分子量:
- 296.75
- MOL File:
- Mol file
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2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽化學性質
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儲存條件:
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−20°C
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溶解度:
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H2O: 10 mg/mL, soluble
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形態(tài):
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solid
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顏色:
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White to off-white
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2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽性質、用途與生產工藝
Cardiogenol C hydrochloride 是一種有效的細胞滲透性嘧啶誘導劑，可促使 ESCs 分化為心肌細胞 (ESCs differentiation into cardiomyocytes) (EC50=100 nM)。Cardiogenol C hydrochloride 還可以在有限的可塑性范圍內對已經沿襲的祖細胞類型產生心肌生成效應。Cardiogenol C hydrochloride 是一種有用的心肌生成試劑，在動物模型中可以用作細胞移植研究中提高心臟修復的工具。
EC50: 100 nM (differentiation of ESCs into cardiomyocytes)
Cardiogenol C hydrochloride (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF,
nppa
) in P19 cells when it compares to untreated control cells.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells.Cardiogenol C hydrochloride (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells.Cardiogenol C hydrochloride (1 μM; 35 days) addition from day 0 significantly increases myocardial differentiation and results in a significantly increased percentage of CBs with beating cardiomyocytes. This small moleculepromotes the development of beating cardiomyocytes in cardiovascular progenitor cell-derived cardiac bodies.Cardiogenol C hydrochloride (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells.
RT-PCR
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Cell Line:
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C2C12 cells
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Concentration:
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0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM
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Incubation Time:
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7 days
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Result:
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Increased
ANF
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NKX2.5
mRNA level as a dose-dependent manner.
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Western Blot Analysis
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Cell Line:
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C2C12 cells
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Concentration:
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0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM
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Incubation Time:
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7 days
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Result:
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Increased cardiac Nav1.5 sodium channel protein levels.
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Cell Proliferation Assay
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Cell Line:
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C2C12 cells
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Concentration:
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0.01 μM; 0.1 μM; 1 μM
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Incubation Time:
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7 days
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Result:
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Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.
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2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽
上下游產品信息
上游原料
下游產品
| 更新日期 | 產品編號 | 產品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽
Cardiogenol C hydrochloride | 1049741-55-0 | 5mg | 600元 |
| 2025/02/08 | HY-12319A | 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽
Cardiogenol C hydrochloride | 1049741-55-0 | 10mM * 1mLin DMSO | 660元 |
2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽
生產廠家
1049741-55-0, 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽 相關搜索:
- Agro Products
- Aromatics
- Agonist
- 抑制劑
- 藥靶配體
- C12H15ClN4O2
- 化合物CARDIOGENOL C HYDROCHLORIDE,10 MM DMSO 溶液
- 化合物 CARDIOGENOL C HYDROCHLORIDE
- 心源醇C 鹽酸鹽
- 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇鹽酸鹽
- 1049741-55-0
- Cardiogen (Myocardium)
- Cardiogenol C hydrochloride, 10 mM in DMSO
- Cardiogenol C hydrochloride(b)
- Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1)
- 2-[[2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl]amino]ethanol hydrochloride (1:1)
- 2-[[2-[(4-Methoxyphenyl)aMino]-4-pyriMidinyl]aMino]ethanol Hydrochloride
- 4-(2-HYDROXYETHYLAMINO)-2-(4-METHOXYPHENYLAMINO)-PYRIMIDINE HYDROCHLORIDE
- CARDIOGENOL C HYDROCHLORIDE