PDK1 抑制劑
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- CAS號(hào):
- 1001409-50-2
- 英文名:
- PDK1 inhibitor
- 英文別名:
- MP7;PDK1 inhibitor;PDK1 inhibitor 7;2-dihydro-2-oxo-;MP7, 10 mM in DMSO;4-difluorophenyl)methyl]-N-[(1R)-2-[(2;3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1;PDK1,MP7,inhibit,Inhibitor,MP 7,kinase-1,PDK-1,phosphoinositide-dependent,MP-7;1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-
- 中文名:
- PDK1 抑制劑
- 中文別名:
- PDK1 抑制劑;PDK1 抑制劑,10 MM DMSO 溶液;PDK1抑制劑(PDK1 INHIBITOR);1-[(3,4-二氟苯基)甲基]-N-[(1R)-2-[(2,3-二氫-2-氧代-1H-苯并咪唑-5-基)氧基]-1-苯基乙基]-1,2-二氫-2-氧代-3-吡啶甲酰胺
- CBNumber:
- CB82624271
- 分子式:
- C28H22F2N4O4
- 分子量:
- 516.5
- MOL File:
- 1001409-50-2.mol
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PDK1 抑制劑化學(xué)性質(zhì)
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沸點(diǎn):
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724.4±60.0 °C(Predicted)
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密度:
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1.398
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Powder
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酸度系數(shù)(pKa):
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11.48±0.20(Predicted)
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顏色:
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Light yellow to yellow
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PDK1 抑制劑性質(zhì)、用途與生產(chǎn)工藝
MP7 (PDK1 inhibitor) 是一種磷酸肌醇依賴性激酶-1 (PDK1) 抑制劑。
Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC
50
values in the micromolar range.
PDK1 抑制劑
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2025/02/08 | HY-14440 | PDK1 抑制劑
MP7 | 1001409-50-2 | 1 mg | 590元 |
| 2025/02/08 | HY-14440 | PDK1 抑制劑
MP7 | 1001409-50-2 | 5mg | 1300元 |
1001409-50-2, PDK1 抑制劑 相關(guān)搜索:
- 抑制劑
- 細(xì)胞生物學(xué)試劑
- C28H22F2N4O4
- PDK1 抑制劑,10 MM DMSO 溶液
- 1-[(3,4-二氟苯基)甲基]-N-[(1R)-2-[(2,3-二氫-2-氧代-1H-苯并咪唑-5-基)氧基]-1-苯基乙基]-1,2-二氫-2-氧代-3-吡啶甲酰胺
- PDK1抑制劑(PDK1 INHIBITOR)
- PDK1 抑制劑
- 1001409-50-2
- MP7, 10 mM in DMSO
- PDK1,MP7,inhibit,Inhibitor,MP 7,kinase-1,PDK-1,phosphoinositide-dependent,MP-7
- PDK1 inhibitor 7
- MP7
- 2-dihydro-2-oxo-
- 3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1
- 4-difluorophenyl)methyl]-N-[(1R)-2-[(2
- 3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-
- 1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
- PDK1 inhibitor