格拉非寧 鹽酸鹽
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- CAS號:
- 65513-72-6
- 英文名:
- 1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE
- 英文別名:
- GlafenineHCl;Glafenin hydrochloride;GLAFENINE HYDROCHLORIDE;1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE;inhibit,Glafenine Hydrochloride,Glafenine,Glafenin,Inhibitor;2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate hydrochloride
- 中文名:
- 格拉非寧 鹽酸鹽
- 中文別名:
- 鹽酸格拉芬寧;格拉非寧 鹽酸鹽;2,3-二羥基丙基2-((7-氯喹啉-4-基)氨基)苯甲酸酯鹽酸鹽
- CBNumber:
- CB8107352
- 分子式:
- C19H18Cl2N2O4
- 分子量:
- 409.26
- MOL File:
- 65513-72-6.mol
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格拉非寧 鹽酸鹽化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMSO : ≥ 60 mg/mL (146.61 mM)
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形態(tài):
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Solid
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顏色:
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Light yellow to yellow
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格拉非寧 鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
Glafenine hydrochloride 是一種非甾體抗炎藥 (NSAID), 具有鎮(zhèn)痛活性。
Glafenine increases the surface expressionof mutant CFTR in baby hamster kidney (BHK) cells to 40% of that observed for wild-type CFTR. Glafenine hydrochloride inhibits the proliferation and clonogenic activity of haSMCs and ECs in a dose-dependent manner. A block in the G2/M phase and a reduction in the G1 phase occurr. The migratory ability of haSMCs is impaired in a dose-dependent manner and the extracellular matrix protein tenascin is reduced.
Glafenine injection (25 mg/kg i.v.) shows enhanced BLI signal in mice with an average of 2.9-fold signal enhancement over the control. Glafenine causes increases in BLI signal of up to 11.6- and 17.4-fold in two separate HEK293/ABCG2/fLuc xenografts in the same mouse compared to the signals generated by those xenografts immediately before injection. Incubating polarized CFBE41o
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monolayers and intestines isolated from mutant CFTR mice with glafenine increases the short-circuit current response to forskolin and genistein. Treatment with glafenine also partially restores total salivary secretion. Glafenine-treated zebrafish shows evidence of endoplasmic reticulum and mitochondrial stress, with disrupted intestinal architecture and halted cell stress responses, alongside accumulation of apoptotic intestinal epithelial cells in the lumen.
格拉非寧 鹽酸鹽
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65513-72-6, 格拉非寧 鹽酸鹽 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 高端化學(xué)
- 小分子抑制劑
- Analytical Chromatography Product Catalog
- Alphabetic
- Analytical Standards
- C19H17ClN2O4HCl
- 3820-57-6
- 鹽酸格拉芬寧
- 2,3-二羥基丙基2-((7-氯喹啉-4-基)氨基)苯甲酸酯鹽酸鹽
- 格拉非寧 鹽酸鹽
- 65513-72-6
- inhibit,Glafenine Hydrochloride,Glafenine,Glafenin,Inhibitor
- 2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate hydrochloride
- Glafenin hydrochloride
- GlafenineHCl
- 1-GLYCERYL N-[7-CHLORO-4-QUINOLYL]ANTHRANILATE HYDROCHLORIDE
- GLAFENINE HYDROCHLORIDE