2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇
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- CAS號:
- 212779-48-1
- 英文名:
- COMPOUND 52
- 英文別名:
- NG-52;N -52;NG-52, >98%;COMPOUND 52;NG 52 (Compound 52 );NG52; COMPOUND52;NG-52;COMPOUND-52;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE;2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol;2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol
- 中文名:
- 2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇
- 中文別名:
- 化合物NG-52;CDC28P和PHO85P激酶抑制劑(NG 52);2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇;2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇, >98%
- CBNumber:
- CB7469930
- 分子式:
- C16H19ClN6O
- 分子量:
- 346.81
- MOL File:
- Mol file
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2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇化學(xué)性質(zhì)
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沸點:
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587.7±60.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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儲存條件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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methylene chloride: 50 mg/mL, clear, colorless
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形態(tài):
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powder
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酸度系數(shù)(pKa):
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14.54±0.10(Predicted)
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顏色:
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white to off-white
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2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇性質(zhì)、用途與生產(chǎn)工藝
NG-52是三取代嘌呤，可結(jié)合酵母CDK的ATP結(jié)合區(qū)域，抑制Cdc28p和Pho85p，IC50分別為7 μM和2 μM。
| Target | Value |
Pho85p
(Cell-free assay)
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2 μM
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Cdc28p
(Cell-free assay)
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7 μM
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NG 52 (Compound 52) inhibits growth in a drug-sensitized yeast strain (
S. cerevisiae
) with a GI
50
of 30 μM. NG 52 is active against cdc2-cyclin B with an IC
50
value of 340 nM.
NG 52 dose-dependently inhibits the proliferation of glioma U87 and U251 cell lines with GI
50
values of 7.8 μM and 5.2 μM, respectively, meanwhile it potently inhibits the proliferation of primary glioma cells.
NG 52 (12.5-50 μM) effectively inhibits the phosphorylation of PDHK1 at Thr338 site and the phosphorylation of PDH at Ser293 site in U87 and U251 cells, resulting in more pyruvic acid entering the Krebs cycle with increased production of ATP and ROS.
NG 52 can reverse the Warburg effect by enhancing the activity of pyruvate dehydrogenase (PDH) through inhibiting the activity of PGK1, and switched cellular glucose metabolism from anaerobic mode to aerobic mode.
Cell Proliferation Assay
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Cell Line:
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Glioma U87 and U251 cells
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Concentration:
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0 μM, 12.5 μM, 25 μM, 50 μM
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Incubation Time:
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6 days
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Result:
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Potently inhibited the proliferation of primary glioma cells.
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Western Blot Analysis
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Cell Line:
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Glioma U87 and U251 cells
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Concentration:
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0 μM, 12.5 μM, 25 μM, 50 μM
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Incubation Time:
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12 hours or 24 hours
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Result:
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Potently inhibited the proliferation of primary glioma cells.
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NG 52 (50-150 mg/kg; oral administration; daily; for 13 days) treatment dose-dependently suppresses the growth of glioma xenograft.
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Animal Model:
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Female
nu/nu
mice (5-week-old) injected with glioma cells
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Dosage:
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50 mg/kg, 100 mg/kg, 150 mg/kg
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Administration:
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Oral administration; daily; for 13 days
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Result:
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Dose-dependently suppressed the growth of glioma xenograft.
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2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2024/11/08 | HY-15154 | NG 52 | | 1 mg | 659元 |
| 2024/11/08 | HY-15154 | 2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇
NG 52 | 212779-48-1 | 5mg | 1451元 |
2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇
生產(chǎn)廠家
212779-48-1, 2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇 相關(guān)搜索:
- Inhibitors
- 抑制劑
- 合成有機(jī)化合物配體
- 細(xì)胞生物學(xué)試劑
- 小分子抑制劑，天然產(chǎn)物
- 小分子抑制劑
- Apoptosis and Cell Cycle
- Cell Biology
- Cell Signaling and Neuroscience
- Cell Cycle
- Cell Cycle Regulators
- BioChemical
- C16H19ClN6O
- 化合物NG-52
- CDC28P和PHO85P激酶抑制劑(NG 52)
- 2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇, >98%
- 2-[[6-[(3-氯苯基)氨基]-9-異丙基-9H-嘌呤-2-基]氨基]乙醇
- 212779-48-1
- N -52
- cdc2-cyclin B,Cyclin dependent kinase,yeast,Pho85p,PGK1,CDK,Cdc28p,anti-proliferation,glioma,inhibit,Compound-52,ROS,ATP,Warburg,Compound52,CDK2,NG 52,ATP-compatible,PDHK1,Inhibitor
- Ethanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-
- NG-52, >98%
- NG52; COMPOUND52;NG-52;COMPOUND-52
- 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
- NG 52 (Compound 52 )
- 2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]ethanol
- 2-((6-((3-chlorophenyl)aMino)-9-isopropyl-9H-purin-2-yl)aMino)ethanol
- 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-52
- COMPOUND 52
- 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
- 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLORANILINO)-9-ISOPROPYLPURINE
- NG-52