214558-72-2
|
|
|
- CAS號:
- 214558-72-2
- 英文名:
- YM-58790
- 英文別名:
- YM-58790;YM58790,YM 58790;YM-58790 hydrochloride
- 中文名:
- 214558-72-2
- 中文別名:
- 化合物 T13372;化合物 YM-58790 HYDROCHLORIDE
- CBNumber:
- CB73175605
- 分子式:
- C27H32ClN3O2
- 分子量:
- 466.02
- MOL File:
- 214558-72-2.mol
|
|
|
214558-72-2化學(xué)性質(zhì)
-
儲存條件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形態(tài):
-
Solid
-
|
-
顏色:
-
Light yellow to yellow
-
|
214558-72-2性質(zhì)、用途與生產(chǎn)工藝
YM-58790 是一種有效的 M3 muscarinic 受體拮抗劑，Ki 值為 15 nM。
Ki: 15 nM (M3 muscarinic receptor)
YM-58790 shows potent inhibitory effect on urinary bladder contraction, but has little effect on bradycardia. YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion in vitro.
YM-58790 (3 mg/kg, i.v.) does not inhibit oxotremorine-induced tremor in mice. The effect of YM-58790 on McN-A343-induced pressor in pithed rats, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.
214558-72-2
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2025/02/08 | HY-101679 | YM-58790 | 214558-72-2 | 1 mg | 1772元 |
| 2025/02/08 | HY-101679 | YM-58790 | 214558-72-2 | 5 mg | 3900元 |
214558-72-2, 214558-72-2 相關(guān)搜索:
- 抑制劑
- 化合物 YM-58790 HYDROCHLORIDE
- 化合物 T13372
- 214558-72-2
- YM-58790 hydrochloride
- YM58790,YM 58790
- YM-58790