1311174-68-1
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- CAS號(hào):
- 1311174-68-1
- 英文名:
- PH002
- 英文別名:
- PH002;PH 002;PH-002;PH002;PH-002;PH 002;PH-002 >=98% (HPLC);inhibit,PH 002,PH-002,Inhibitor,PH002;4-[[4-[[2-(3,4-Dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;1-Piperazinecarboxylic acid, 4-[[4-[[2-(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester
- 中文名:
- 1311174-68-1
- 中文別名:
- 化合物PH-002;4-(4-(2-(3-甲基-4-氧代-3,4-二氫酞嗪-1-基)乙酰氨基)芐基)哌嗪-1-甲酸叔丁酯;4-[[[4-[[2-(3,4-二氫-3-甲基-4-氧代-1-酞嗪基)乙?；鵠氨基]苯基]甲基]-1-哌嗪羧酸叔丁酯
- CBNumber:
- CB72751059
- 分子式:
- C27H33N5O4
- 分子量:
- 491.58
- MOL File:
- 1311174-68-1.mol
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1311174-68-1化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble10mg/mL (clear solution)
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形態(tài):
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powder
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顏色:
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white to beige
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1311174-68-1性質(zhì)、用途與生產(chǎn)工藝
PH-002 是一種抑制載脂蛋白 (apo) E4 神經(jīng)內(nèi)分子相互作用的抑制劑，其 IC50 (FRET) 值為116 nM。
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an
IC
50
of 116 nM in FRET.
PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by ~60%. PH-002 (100 nM) increases dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons).
1311174-68-1
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-112798 | PH-002 | | 1 mg | 520元 |
| 2024/11/08 | HY-112798 | 1311174-68-1
PH-002 | 1311174-68-1 | 5mg | 1300元 |
1311174-68-1, 1311174-68-1 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 化合物PH-002
- 4-(4-(2-(3-甲基-4-氧代-3,4-二氫酞嗪-1-基)乙酰氨基)芐基)哌嗪-1-甲酸叔丁酯
- 4-[[[4-[[2-(3,4-二氫-3-甲基-4-氧代-1-酞嗪基)乙酰基]氨基]苯基]甲基]-1-哌嗪羧酸叔丁酯
- 1311174-68-1
- inhibit,PH 002,PH-002,Inhibitor,PH002
- PH-002 >=98% (HPLC)
- 1-Piperazinecarboxylic acid, 4-[[4-[[2-(3,4-dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-, 1,1-dimethylethyl ester
- PH002;PH-002;PH 002
- PH-002
- PH002
- PH 002
- 4-[[4-[[2-(3,4-Dihydro-3-methyl-4-oxo-1-phthalazinyl)acetyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester