NU6140
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- CAS號(hào):
- 444723-13-1
- 英文名:
- NU6140
- 英文別名:
- NU6140;4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide;4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide;Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-;CDK,Inhibitor,NU6140,Aurora Kinase,inhibit,NU 6140,NU-6140,Cyclin dependent kinase
- 中文名:
- NU6140
- 中文別名:
- 化合物NU6140;NU 6140,CDK2抑制劑;4-((6-(環(huán)己基甲氧基)-7H-嘌呤-2-基)氨基)-N,N-二乙基苯甲酰胺
- CBNumber:
- CB71114327
- 分子式:
- C23H30N6O2
- 分子量:
- 422.52
- MOL File:
- 444723-13-1.mol
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NU6140化學(xué)性質(zhì)
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沸點(diǎn):
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707.8±70.0 °C(Predicted)
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密度:
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1.234±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Desiccate at +4°C
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
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形態(tài):
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White to off-white solid.
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酸度系數(shù)(pKa):
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9.41±0.10(Predicted)
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顏色:
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White to light yellow
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NU6140性質(zhì)、用途與生產(chǎn)工藝
NU6140 是一種選擇性的 CDK2-cyclin A 抑制劑 (IC50，0.41 μM)，對(duì)其選擇性是對(duì)其他 CDK 的 10-36 倍。NU6140 有效抑制 Aurora A 和 Aurora B 的活性，IC50 值分別為 67 和 35 nM。增強(qiáng)誘導(dǎo)凋亡的作用，抗腫瘤作用。
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cdk2-cyclin A
0.41 μM (IC
50
)
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CDK1-Cyclin B
6.6 μM (IC
50
)
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CDK4-Cyclin D
5.5 μM (IC
50
)
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cdk5-p25
15 μM (IC
50
)
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cdk7-cyclin H
3.9 μM (IC
50
)
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Aurora A
67 nM (IC
50
)
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Aurora B
35 nM (IC
50
)
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NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H, with IC
50
s of 6.6, 5.5, 15 and 3.9 μM, respectively.
NU6140 increases catalytic activity of capase-9 and capase-3, causes increase in the sub-G1 apoptotic cell population.
NU6140
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2024/11/08 | HY-107419 | NU6140
NU6140 | 444723-13-1 | 5mg | 1200元 |
| 2024/11/08 | HY-107419 | NU6140
NU6140 | 444723-13-1 | 10mM * 1mLin DMSO | 1320元 |
444723-13-1, NU6140 相關(guān)搜索:
- 抑制劑
- 合成有機(jī)化合物配體
- NU 6140,CDK2抑制劑
- 化合物NU6140
- 4-((6-(環(huán)己基甲氧基)-7H-嘌呤-2-基)氨基)-N,N-二乙基苯甲酰胺
- 444723-13-1
- CDK,Inhibitor,NU6140,Aurora Kinase,inhibit,NU 6140,NU-6140,Cyclin dependent kinase
- Benzamide, 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-N,N-diethyl-
- 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]-N,N-diethylbenzamide
- 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide
- NU6140