501698-03-9
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- CAS號:
- 501698-03-9
- 英文名:
- GDP366
- 英文別名:
- GDP366;GDP366, 10 mM in DMSO;GDP366;GDP-366;GDP 366;GDP-366,Survivin,GDP 366,inhibit,GDP366,Inhibitor;1-(4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-3-(m-tolyl)urea;Urea, N-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N'-(3-methylphenyl)-
- 中文名:
- 501698-03-9
- 中文別名:
- 化合物GDP366;化合物 T11383;化合物GDP366,10 MM DMSO 溶液;1-(4-(4-氨基噻吩并[2,3-D]嘧啶-5-基)苯基)-3-(間甲苯基)脲
- CBNumber:
- CB63339657
- 分子式:
- C20H17N5OS
- 分子量:
- 375.45
- MOL File:
- 501698-03-9.mol
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501698-03-9化學(xué)性質(zhì)
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熔點(diǎn):
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227-228 °C(Solv: ethanol (64-17-5))
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沸點(diǎn):
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538.5±50.0 °C(Predicted)
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密度:
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1.423±0.06 g/cm3(Predicted)
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儲存條件:
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2-8°C(protect from light)
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溶解度:
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DMSO:62.5(Max Conc. mg/mL);166.47(Max Conc. mM)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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14.22±0.70(Predicted)
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顏色:
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Light yellow to yellow
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501698-03-9性質(zhì)、用途與生產(chǎn)工藝
GDP366 是 survivin 和 Op18 的雙重抑制劑，抑制癌細(xì)胞生長，誘導(dǎo)細(xì)胞衰老和有絲分裂突變。
GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity.
501698-03-9
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2025/02/08 | HY-U00177 | GDP366 | 501698-03-9 | 1 mg | 2095元 |
| 2025/02/08 | HY-U00177 | 501698-03-9
GDP366 | 501698-03-9 | 5mg | 5500元 |
501698-03-9, 501698-03-9 相關(guān)搜索:
- 抑制劑
- 化合物GDP366,10 MM DMSO 溶液
- 化合物GDP366
- 化合物 T11383
- 1-(4-(4-氨基噻吩并[2,3-D]嘧啶-5-基)苯基)-3-(間甲苯基)脲
- 501698-03-9
- GDP366, 10 mM in DMSO
- GDP-366,Survivin,GDP 366,inhibit,GDP366,Inhibitor
- 1-(4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-3-(m-tolyl)urea
- Urea, N-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N'-(3-methylphenyl)-
- GDP366;GDP-366;GDP 366
- GDP366