6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽
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- CAS號(hào):
- 174634-09-4
- 英文名:
- TAS 103
- 英文別名:
- CS-1342;TAS-103(2HCl);BMS-247615-2HCl;TAS-103(BMS-247615);TAS 103 (hydrochloride);BMS247615 dihydrochloride;BMS-247615 dihydrochloride;BMS 247615 dihydrochloride;TAS-103 (dihydrochloride);TAS-103 HCl salt (BMS-247615)
- 中文名:
- 6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽
- 中文別名:
- TAS-103雙鹽酸鹽;TAS-103(BMS-247615)鹽;拓?fù)洚悩?gòu)酶I和II抑制劑(TAS-103雙鹽酸鹽);化合物TAS-103 (DIHYDROCHLORIDE);6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽
- CBNumber:
- CB62668727
- 分子式:
- C20H21Cl2N3O2
- 分子量:
- 406.30564
- MOL File:
- 174634-09-4.mol
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6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽化學(xué)性質(zhì)
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儲(chǔ)存條件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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PBS (pH 7.2):1.0(Max Conc. mg/mL);2.46(Max Conc. mM)
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形態(tài):
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A crystalline solid
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顏色:
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Brown to orange
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6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽性質(zhì)、用途與生產(chǎn)工藝
TAS-103 dihydrochloride 是一種 DNA 拓?fù)洚悩?gòu)酶 I/II (topoisomerase I/II) 雙重抑制劑，可用于癌癥研究。
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Topoisomerase I
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Topoisomerase II
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TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC
50
value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103. TAS-103 inhibits the viability of HeLa cells, with an IC
50
of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation.
TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103.
6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2024/11/08 | HY-13758A | TAS-103 dihydrochloride | | 1 mg | 500元 |
| 2024/11/08 | HY-13758A | 6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽
TAS-103 dihydrochloride | 174634-09-4 | 5mg | 1100元 |
6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽
生產(chǎn)廠家
174634-09-4, 6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽 相關(guān)搜索:
- 抑制劑
- 細(xì)胞生物學(xué)試劑
- C20H19N3O22HCl
- 化合物TAS-103 (DIHYDROCHLORIDE)
- TAS-103雙鹽酸鹽
- TAS-103(BMS-247615)鹽
- 拓?fù)洚悩?gòu)酶I和II抑制劑(TAS-103雙鹽酸鹽)
- 6-[[2-(二甲基氨基)乙基]氨基]-3-羥基-7H-茚并[2,1-C]喹啉-7-酮二鹽酸鹽
- 174634-09-4
- TAS-103 HCl salt (BMS-247615)
- BMS247615,Topoisomerase,TAS-103,TAS103,inhibit,TAS 103 dihydrochloride,BMS-247615,Inhibitor,TAS103 dihydrochloride,TAS 103,BMS 247615
- TAS 103 (hydrochloride)
- TAS 103 dihydrochloride, BMS 247615 dihydrochloride
- CS-1342
- TAS-103;TAS103; BMS 247615; BMS-247615; BMS-247615 DIHYDROCHLORIDE; TAS103 DIHYDROCHLORIDE; TAS 103 DIHYDROCHLORIDE; BMS247615 DIHYDROCHLORIDE; BMS 247615 DIHYDROCHLORIDE
- BMS-247615 dihydrochloride
- BMS247615 dihydrochloride
- BMS 247615 dihydrochloride
- BMS-247615-2HCl
- 6-[[2-(Dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride
- TAS-103(BMS-247615)
- TAS-103(2HCl)
- TAS-103 (dihydrochloride)