GR 82334
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- CAS號:
- 129623-01-4
- 英文名:
- GR 82334
- 英文別名:
- GR 82334;pglu-ala-asp-pro-asn-lys-phe-tyr-pro(spiro-γ-lactam-leu-trp-nh2;[[(S,S)PRO-LEU(SPIRO-GAMMA-LACTAM)]9,10, TRP11]PHYSALAEMIN (1-11);PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-PRO(SPIRO-GAMMA-LACTAM)-LEU-TRP-NH2;L-Tryptophanamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosyl-(αS,5S)-α-(2-methylpropyl)-6-oxo-1,7-diazaspiro[4.4]nonane-7-acetyl-
- 中文名:
- 中文別名:
- CBNumber:
- CB5476231
- 分子式:
- C69H91N15O16
- 分子量:
- 1386.55
- MOL File:
- 129623-01-4.mol
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GR 82334化學(xué)性質(zhì)
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沸點:
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1788.6±65.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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儲存條件:
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−20°C
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形態(tài):
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Powder
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酸度系數(shù)(pKa):
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4.31±0.19(Predicted)
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水溶解性:
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Soluble to 1 mg/ml in water
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GR 82334性質(zhì)、用途與生產(chǎn)工藝
GR 82334 是一種有效的、特異性的可逆速激蛋白 NK1 受體 (tachykinin NK1 receptor) 拮抗劑。GR 82334 通過阻斷 NK1 受體的作用，抑制大鼠神經(jīng)肽 P 物質(zhì)誘導(dǎo)的致敏作用。
GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul).GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency.
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Animal Model:
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3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats
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Dosage:
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10 nM, 100 nM, and 1 μM
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Administration:
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Lntrathecal injection between vertebrae L4 and L5
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Result:
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Increased heat-induced foot withdrawal latency in mice.
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GR 82334
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
129623-01-4, GR 82334 相關(guān)搜索:
- Amino Acids and Peptides
- Biochemicals and Reagents
- BioChemical
- Antagonist
- Tachykinins
- Peptides
- C69H91N15O16
- 129623-01-4
- L-Tryptophanamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosyl-(αS,5S)-α-(2-methylpropyl)-6-oxo-1,7-diazaspiro[4.4]nonane-7-acetyl-
- pglu-ala-asp-pro-asn-lys-phe-tyr-pro(spiro-γ-lactam-leu-trp-nh2
- [[(S,S)PRO-LEU(SPIRO-GAMMA-LACTAM)]9,10, TRP11]PHYSALAEMIN (1-11)
- PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-PRO(SPIRO-GAMMA-LACTAM)-LEU-TRP-NH2
- GR 82334