化合物 T22898
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- CAS號(hào):
- 145455-35-2
- 英文名:
- L-692,585
- 英文別名:
- 585;L-692;L-692,585;L 692585,L692585;3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide;3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide;Butanamide, 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
- 中文名:
- 化合物 T22898
- 中文別名:
- 化合物 T22898;化合物 L-692585
- CBNumber:
- CB4819480
- 分子式:
- C32H37N7O3
- 分子量:
- 567.68
- MOL File:
- 145455-35-2.mol
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化合物 T22898化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Desiccate at -20°C
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溶解度:
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Soluble to 100 mM in DMSO and to 25 mM in ethanol
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形態(tài):
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Powder
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顏色:
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White to off-white
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化合物 T22898性質(zhì)、用途與生產(chǎn)工藝
L-692585 是一種有效的非肽基生長(zhǎng)激素促分泌素受體 (GHS-R1a) 激動(dòng)劑，Ki 值為 0.8 nM。L-692585 可直接作用于生長(zhǎng)激素，誘導(dǎo) GH 釋放。
L-692585 (10 μM; 2 min) produces a prompt transient increase in [Ca
2+
]
i
, following by the sustained decline to a plateau above the basal level in GH cells.
L-692585 (0.01-10 μM; 2 min) induces release of growth hormone (GH) in a dose-dependent manner from isolated porcine somatotropes.
L-692585 (100 nM) signi?cantly increases the number and size of plaques, and it also causes a signi?cant increase in total secretion index (TSI) .
L-692585 (0.01-0.1 mg/kg; i.v. once daily for 2 weeks) increases peak plasma GH levels and total GH release.
L-692585 (0.005-0.1 mg/kg; a single i.v.) significantly increases peak GH concentrations 4.3-fold at a dose of 0.005 mg/kg, 7-fold at a dose of 0.02 mg/kg, and 21-fold at a dose of 0.10 mg/kg in vivo.
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Animal Model:
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Beagles (1-1.5 years old ; weighting 8.5-16.0 kg)
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Dosage:
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0.01, 0.1 mg/kg
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Administration:
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I.v. once daily for 2 weeks
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Result:
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Increased the peak plasma GH levels and total GH release on days 1, 8 and 15 in a dose-dependent manner, and no desensitization was evident.
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化合物 T22898
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
145455-35-2, 化合物 T22898 相關(guān)搜索:
- 抑制劑
- C32H37N7O3
- 化合物 L-692585
- 化合物 T22898
- 145455-35-2
- L 692585,L692585
- 585
- Butanamide, 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
- 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide
- 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide
- L-692
- L-692,585