SC 66
|
|
|
- CAS號:
- 871361-88-5
- 英文名:
- SC 66
- 英文別名:
- SC 66;CS-2480;SC66;SC 66;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
- 中文名:
- SC 66
- 中文別名:
- 化合物SC66;AKT抑制劑(SC66);(2E,6E)-2,6-二(4-吡啶基亞甲基)環(huán)己酮
- CBNumber:
- CB42565930
- 分子式:
- C18H16N2O
- 分子量:
- 276.33
- MOL File:
- 871361-88-5.mol
|
|
|
SC 66化學(xué)性質(zhì)
-
儲存條件:
-
Sealed in dry,2-8°C
-
|
-
溶解度:
-
DMSO: ≥5mg/mL (warmed)
-
|
-
形態(tài):
-
powder
-
|
-
顏色:
-
faint yellow to dark yellow
-
|
SC 66性質(zhì)、用途與生產(chǎn)工藝
SC66 是一種 Akt 抑制劑，降低細(xì)胞活力，這種作用存在劑量和時間依賴性，且抑制肝癌 (HCC) 細(xì)胞的集落形成和誘導(dǎo)凋亡。
SC66 inhibits cell viability and colony forming capacity of HCC cells with IC
50
s of 0.77，0.47，0.92，0.75 and 2.85 μg/mL at 72 hours for HepG2, Hep3B, PLC/PRF/5，HA22T/VGH and Huh7 cells. HepG2, HA22T/VGH and PLC/PRF/5 cells have similar IC
50
s of approximately 0.85 and 0.75 μg/mL at 48 and 72 hours, respectively. To determine whether the decrease in cell viability is related to apoptosis induction, TUNEL assays are performed in Hep3B and Huh7 cells treated with 1, 2 and 4 μg/mL of SC66 for 24 hours. In Hep3B cells the number of TUNEL-positive cells increased with increasing concentrations of SC66, whereas in Huh7 cells very few light brown-colored cells are observed only after treatment with 4 μg/mL SC66.
To demonstrate the effectiveness in vivo of SC66 on HCC, a mouse xenograft tumor model of Hep3B cells is used. When tumors became palpable, at a size of about 150 mm
3
, mice are randomized into three groups of 6 animals each. The treated group receive SC66 at 15 and 25 mg/kg twice a week via i.p. injection, while the untreated group receive the vehicle alone. Treatment with 25 mg/Kg SC66 significantly reduces tumor volume to 37% on day 17 when compared with tumors of the untreated group.
SC 66
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2024/11/08 | HY-19832 | SC 66
SC66 | 871361-88-5 | 5mg | 550元 |
| 2024/11/08 | HY-19832 | SC 66
SC66 | 871361-88-5 | 10mM * 1mLin DMSO | 605元 |
871361-88-5, SC 66 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 細(xì)胞生物學(xué)試劑
- 化合物SC66
- AKT抑制劑(SC66)
- (2E,6E)-2,6-二(4-吡啶基亞甲基)環(huán)己酮
- 871361-88-5
- 2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA
- Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
- (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone
- SC66;SC 66
- CS-2480
- (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
- Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
- SC 66