5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物
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- CAS號:
- 73360-56-2
- 英文名:
- 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate
- 英文別名:
- Cestocide;Zestocarp;Glumetinib Impurity 16;2',5-D733ichloro-4'-nitrosalicylanilide Hydrate;N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylaMide Hydrate;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzaMide Hydrate;5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate
- 中文名:
- 5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物
- 中文別名:
- 氯硝柳胺一水物;氯硝柳胺 一水合物;化合物 T23068;5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物
- CBNumber:
- CB42484703
- 分子式:
- C13H8Cl2N2O4.H2O
- 分子量:
- 345.14
- MOL File:
- 73360-56-2.mol
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5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物化學(xué)性質(zhì)
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熔點:
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224-229℃
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物性質(zhì)、用途與生產(chǎn)工藝
Niclosamide monohydrate 是一種 STAT3 抑制劑，在 HeLa 細(xì)胞中，IC50 值為 0.25 μM，可以抑制 DNA 復(fù)制。
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STAT3
0.25 μM (IC
50
, in HeLa cells)
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Niclosamide monohydrate is an inhibitor of STAT3, inhibits STAT3-mediated luciferase reporter activity with an IC
50
of 0.25 μM in HeLa cells. Niclosamide (1 μM) inhibits the EGF-induced nuclear translocation of STAT3 in Du145 cells. Niclosamide (< 2 μM) dose dependently inhibits the transcription of STAT3 downstream genes in Du145 cells. Niclosamide (< 10 μM) induces G0/G1 arrest and apoptosis of Du145 cancer cells in a dose dependent manner. Niclosamide can block SARS-CoV replication at a micromolar concentration in Vero E6 cells infected with SARS-CoV. Niclosamide (< 7.5 μM) promotes Frizzled1 endocytosis, downregulates Dishevelled-2 protein, and inhibits Wnt3A-stimulated beta-catenin stabilization and LEF/TCF reporter activity in U2OS cells. Niclosamide inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. Niclosamide (125 nM) inhibits NF-κB activation induced by p65, IKKα, IKKβ, IKKγ, and TAK1 in U2OS cells. Niclosamide (< 500 nM) completely block the time- and dose-dependent TNFα-induced alteration of the NF-κB-DNA complex in HL-60 cells. Niclosamide (< 10 nM) inhibits constitutive NF-κB activation in U266 cells. Niclosamide inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Niclosamide (500 nM) causes decrease in TNF-induced NF-κB-dependent gene products involved in cell survival in HL-60 cells. Niclosamide also inhibits the growth and induces robust apoptosis of AML cells associated with decreased Mcl-1 and XIAP levels and increased intracellular ROS levels.
Niclosamide (40 mg/kg/d, i.p.) suppresses growth of xenografted AML cells in nude mice bearing HL-60 xenograft tumors.
5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物
生產(chǎn)廠家
73360-56-2, 5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物 相關(guān)搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Aromatics
- Amines
- 抑制劑
- 化工原料
- C13H10Cl2N2O5
- C13H8Cl2N2O4H2O
- 化合物 T23068
- 氯硝柳胺一水物
- 氯硝柳胺 一水合物
- 5-氯-N-(2-氯-4-硝基苯基)-2-羥基苯甲酰胺一水合物
- 73360-56-2
- Glumetinib Impurity 16
- Zestocarp
- N-(2-Chloro-4-nitrophenyl)-5-chlorosalicylaMide Hydrate
- Cestocide
- 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzaMide Hydrate
- 2',5-D733ichloro-4'-nitrosalicylanilide Hydrate
- 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide monohydrate