ChemicalBook CAS DataBase List 2-AMINO-4-FLUOROPYRIDINE

2-AMINO-4-FLUOROPYRIDINE synthesis

10synthesis methods

Product Name:2-AMINO-4-FLUOROPYRIDINE
CAS Number:944401-77-8
Molecular formula:C5H5FN2
Molecular Weight:112.11

19798-80-2 Synthesis

19798-80-2
534 suppliers
$6.00/1g

944401-77-8
225 suppliers
$17.00/1g

Yield:944401-77-8 90%

Reaction Conditions:

with sodium fluoride in N,N-dimethyl-formamide at 140;Solvent;Reagent/catalyst;Temperature;

Steps:

2
The 28 g 2 - amino -4 - chloro pyridine is added to the 100 ml of N, N - dimethyl formamide in, adding 46 g sodium fluoride, reaction 140 °C reaction 5 - 8 hours, cooling to 80 °C, pressure reducing and recovering the solvent, the residue is added in dichloromethane and saturated salt water distribution, organic phase solvent, ethanol recrystallization to obtain 2 - amino 4 - fluoro pyridine, white solid, 22 g, yield 90%.

References:

Shanghai Lingkai Pharmaceutical Technology Co., Ltd.;Liang Zhujun CN108440402, 2018, A Location in patent:Paragraph 0008; 0020; 0023-0024; 0027-0028; 0031

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