鹽酸螺普利
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- CAS號(hào):
- 94841-17-5
- 英文名:
- Spirapril hydrochloride
- 英文別名:
- Renpress;Renormax;Sandopril;TI 211-950;Spirapril HCl;Unii-occ25lm897;Spirapril hydrochloride;Spirapril for system suitability CRS;Spirapril hydrochloride monohydrate CRS;Spirapril Hydrochloride Solution, 100ppm
- 中文名:
- 鹽酸螺普利
- 中文別名:
- 鹽酸螺普利;螺普利鹽酸鹽;鹽酸螺普利/A1A;螺普利系統(tǒng)適用性 EP標(biāo)準(zhǔn)品;鹽酸螺普利一水合物 EP標(biāo)準(zhǔn)品;鹽酸螺普利溶液,1000PPM;鹽酸螺普利溶液, 100PPM;螺普利/用于系統(tǒng)適用性試驗(yàn)/A1A;藥典對(duì)照品/螺普利/用于系統(tǒng)適用性試驗(yàn)/A1A;化合物 SPIRAPRIL HYDROCHLORIDE
- CBNumber:
- CB3951251
- 分子式:
- C22H30N2O5S2.HCl
- 分子量:
- 503.07
- MOL File:
- 94841-17-5.mol
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鹽酸螺普利化學(xué)性質(zhì)
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熔點(diǎn):
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192-1940C (dec.)
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比旋光度:
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D26 -11.2° (c = 0.4 in ethanol)
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儲(chǔ)存條件:
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-20°C Freezer
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溶解度:
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Very slightly soluble in water, soluble in methanol, slightly soluble in acetonitrile, practically insoluble in methylene chloride.
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形態(tài):
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Solid
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顏色:
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White to Off-White
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穩(wěn)定性:
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Hygroscopic
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鹽酸螺普利性質(zhì)、用途與生產(chǎn)工藝
Spirapril (SCH 33844) hydrochloride 是一種有效的血管緊張素轉(zhuǎn)換酶 (ACE) 抑制劑，具有降壓作用。Spirapril hydrochloride 競(jìng)爭(zhēng)性地與 ACE 結(jié)合，阻止血管緊張素I向血管緊張素 II 的轉(zhuǎn)化。Spirapril hydrochloride 是螺普利拉的一種口服活性前藥，可用于高血壓、充血性心力衰竭的研究。
IC50: angiotensin converting enzyme
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice. It crosses the blood-brain barrier and suppresses the transgene effect in the experiments.
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Animal Model:
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TGM123 mice (expressing a rat angiotensinogen transgene) and TLM ( lacking the angiotensinogen gene) mice
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Dosage:
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10 mg/kg
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Administration:
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Feeding needle; 10 mg/kg; 3 weeks
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Result:
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Alter voluntary alcohol consumption in animals.
Crossed the blood-brain barrier and may influences alcohol consumption mainly by decreasing central angiotensin II (AII) levels.
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鹽酸螺普利
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2025/02/08 | HY-A0230A | 鹽酸螺普利
Spirapril hydrochloride | 94841-17-5 | 1 mg | 1409元 |
| 2025/02/08 | HY-A0230A | 鹽酸螺普利
Spirapril hydrochloride | 94841-17-5 | 5 mg | 3100元 |
94841-17-5, 鹽酸螺普利 相關(guān)搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- API
- 抑制劑
- C22H30N2O5S2ClH
- C22H30N2O5S2HCl
- C22H31ClN2O5S2
- 藥典對(duì)照品/螺普利/用于系統(tǒng)適用性試驗(yàn)/A1A
- 鹽酸螺普利/A1A
- 螺普利鹽酸鹽
- 螺普利/用于系統(tǒng)適用性試驗(yàn)/A1A
- 化合物 SPIRAPRIL HYDROCHLORIDE
- 螺普利系統(tǒng)適用性 EP標(biāo)準(zhǔn)品
- 鹽酸螺普利一水合物 EP標(biāo)準(zhǔn)品
- 鹽酸螺普利溶液,1000PPM
- 鹽酸螺普利溶液, 100PPM
- 鹽酸螺普利
- 94841-17-5
- Spirapril for system suitability CRS
- Spirapril hydrochloride monohydrate CRS
- Spirapril Hydrochloride Solution, 1000ppm
- (8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid:hydrochloride
- Spirapril Hydrochloride Solution, 100ppm
- (8S)-7-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic Acid Monohydrochloride
- Spirapril hydrochloride
- Unii-occ25lm897
- Spirapril HCl
- 1,4-Dithia-7-azaspiro(4.4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, monohydrochloride, (8S-(7(R*(R*)),8R*))-
- TI 211-950
- Sandopril
- Renpress
- Renormax