1-Boc-吡唑-4-硼酸頻哪醇酯性質(zhì)、用途與生產(chǎn)工藝

性質(zhì)

1-Boc-吡唑-4-硼酸頻哪醇酯在常溫常壓下呈白色或者米白色固體狀。

用途

1-Boc-吡唑-4-硼酸頻哪醇酯屬于吡唑類(lèi)衍生物，主要用作藥物分子和生物活性分子的合成中間體。在合成轉(zhuǎn)化中，吡唑環(huán)上的硼單元是一個(gè)非常實(shí)用的官能團(tuán)轉(zhuǎn)化前體，硼單元可以很容易地轉(zhuǎn)化為氮原子，也可以很容易被氧化成羥基，或者通過(guò)Suzuki偶聯(lián)反應(yīng)在硼單元的位置連接上一個(gè)芳基或者烷基基團(tuán)。

合成方法

將氯(1,5-環(huán)辛二烯)(1,1'-菲羅啉)銥四氫呋喃加合物(5.8 mg, 0.01 mmol, 0.5 mol%)和聯(lián)硼酸頻哪醇酯加入到一個(gè)敞口的反應(yīng)瓶中，用一個(gè)帶隔膜的螺旋蓋密封小瓶，通過(guò)在真空下進(jìn)行三次循環(huán)抽真空來(lái)對(duì)小瓶進(jìn)行氮?dú)庵脫Q。在第二個(gè)燒瓶中制備頻那醇硼烷（0.050 mL，44.1 mg，0.344 mmol）在四氫呋喃（50 mL，0.0067 M）中的儲(chǔ)備溶液。將儲(chǔ)備溶液（1.4毫升，1當(dāng)量的頻那醇硼烷）注射到氯（1,5-環(huán)辛二烯）（1,1'-菲羅啉）銥四氫呋喃加合物和硼酸頻哪醇酯的混合體系中去，將所得的反應(yīng)混合物加熱到65度反應(yīng)1小時(shí)，直到形成暗紅色溶液。將0.336克1H-吡唑-1-甲酸叔丁酯直接加入暗紅色溶液中，讓其反應(yīng)若干個(gè)小時(shí)，通過(guò)GC、GC-MS和TLC監(jiān)測(cè)反應(yīng)的進(jìn)展。當(dāng)反應(yīng)完成后，冷卻小瓶，通過(guò)硅藻土過(guò)濾除去固體沉淀，得到的濾液真空下蒸發(fā)旋干，用二氯甲烷溶解所得的殘余物，通過(guò)柱色譜法（0:100-1:1 乙酸乙酯和正己烷）提純分離殘余物即可得到目標(biāo)產(chǎn)物1-Boc-吡唑-4-硼酸頻哪醇酯。

圖 1-Boc-吡唑-4-硼酸頻哪醇酯的合成路線

1-Boc-吡唑-4-硼酸頻哪醇酯 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

1-Boc-吡唑-4-硼酸頻哪醇酯 試劑級(jí)價(jià)格

更新日期	產(chǎn)品編號(hào)	產(chǎn)品名稱(chēng)	CAS編號(hào)	包裝	價(jià)格
2025/02/08	XW5528461702	1-BOC-吡唑-4-硼酸頻哪醇酯 1-(tert-butoxycarbonyl)pyrazolyl-4-boronic acid pinacol ester;1-boc-pyrazolyl-4-boronic acid pinacol ester;1-(tert-butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;2-(1-boc-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(1-tert-butoxycarbonyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-carboxylic acid tert-butyl ester	552846-17-0	5G	58元
2025/02/08	XW5528461701	1-BOC-吡唑-4-硼酸頻哪醇酯 1-(tert-butoxycarbonyl)pyrazolyl-4-boronic acid pinacol ester;1-boc-pyrazolyl-4-boronic acid pinacol ester;1-(tert-butoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;2-(1-boc-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(1-tert-butoxycarbonyl-4-pyrazolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate;4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-carboxylic acid tert-butyl ester	552846-17-0	1G	33元

1-Boc-吡唑-4-硼酸頻哪醇酯 生產(chǎn)廠家

 

552846-17-0, 1-Boc-吡唑-4-硼酸頻哪醇酯 相關(guān)搜索:

• Boric Acid| Boric Acid Ester| Potassium Trifluoroborate
• 化學(xué)試劑
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• 化學(xué)試劑-有機(jī)試劑
• 有機(jī)化學(xué)
• 硼酸及其衍生物
• 醫(yī)藥中間體
• 硼酸
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• tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
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• 1-(tert-Butoxycarbonyl)pyrazolyl-4-boronic Acid Pinacol Ester
• 1-Boc-pyrazolyl-4-boronic Acid Pinacol Ester
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