(ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
|
|
|
- CAS號:
- 57046-73-8
- 英文名:
- Paprotrain
- 英文別名:
- Paprotrain;Kinesin,Paprotrain,Inhibitor,inhibit;2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile;(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile;(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
- 中文名:
- (ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
- 中文別名:
- 化合物PAPROTRAIN;(Z)-2-(1H-吲哚-3-基)-3-(吡啶-3-基)丙烯腈;(ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
- CBNumber:
- CB32677878
- 分子式:
- C16H11N3
- 分子量:
- 245.28
- MOL File:
- 57046-73-8.mol
|
|
|
(ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈化學性質(zhì)
-
熔點:
-
202℃
-
|
-
儲存條件:
-
2-8°C
-
|
-
溶解度:
-
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
-
|
-
形態(tài):
-
Powder
-
|
-
顏色:
-
Light yellow to yellow
-
|
(ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈性質(zhì)、用途與生產(chǎn)工藝
Paprotrain是可滲透細胞的kinesin MKLP-2 的抑制劑，抑制 MKLP-2 的 ATPase 活性，IC50 值為 1.35 μM，Ki 值為 3.36 μM，同時對 DYRK1A 有中等的抑制作用，IC50值為 5.5 μM。
Paprotrain has been screened on a panel of CNS kinases. While inactive (IC
50
>10 μM) on CDK5 and GSK3, it has shown a moderate activity on DYRK1A (IC
50
=5.5 μM). Time-lapse microscopy shows that disrupting MKlp2 expression with paprotrain results in polar body extrusion failure. This could be rescued after rescuing oocytes from paprotrain in fresh medium. Cell cycle analysis shows that most oocytes are arrested at metaphase I or telophase I. However, oocyte spindle structure and chromosome alignment are not disrupted after the inhibition of MKlp2 by paprotrain. Paprotrain-treated porcine oocytes suffer failure of nuclear maturation. The number of oocytes arrested at early MI stage increase in a dose-dependent manner after KIF20A activity inhibition, while the percentage of oocytes that reach ATI and MII stages decrease after treatment.
(ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2024/11/08 | HY-101298 | (ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
Paprotrain | 57046-73-8 | 5mg | 500元 |
| 2024/11/08 | HY-101298 | (ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
Paprotrain | 57046-73-8 | 10mM * 1mLin DMSO | 550元 |
(ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
生產(chǎn)廠家
57046-73-8, (ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈 相關搜索:
- 抑制劑
- 藥靶配體
- 化合物PAPROTRAIN
- (Z)-2-(1H-吲哚-3-基)-3-(吡啶-3-基)丙烯腈
- (ALPHAZ)-ALPHA-(3-吡啶基亞甲基)-1H-吲哚-3-乙腈
- 57046-73-8
- (Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile
- Kinesin,Paprotrain,Inhibitor,inhibit
- 1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-
- (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
- 2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile
- (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
- Paprotrain