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  2. Epigenetics Anti-infection
  3. Histone Methyltransferase Fungal Antibiotic Parasite
  4. Sinefungin

Sinefungin  (Synonyms: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP)

目錄號: HY-101938 純度: 99.91%
COA 產(chǎn)品使用指南 技術(shù)支持

Sinefungin是病毒粒子mRNA (鳥嘌呤-7-)-甲基轉(zhuǎn)移酶、 mRNA (核苷-2'-)-甲基轉(zhuǎn)移酶和病毒增殖的有效抑制劑。Sinefungin 是一種 SET7/9 抑制劑，通過抑制H3K4甲基化來改善腎纖維化。

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Sinefungin Chemical Structure

Sinefungin Chemical Structure

CAS No. : 58944-73-3

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥3188
In-stock
1 mg ￥3000
In-stock
5 mg ￥3800
In-stock
10 mg ￥6000
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 CC50
72.93 μM
Compound: Sinefungin
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by neutral red uptake assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by neutral red uptake assay
[PMID: 34257831]
HEK293 CC50
> 500 μM
Compound: SFG
Cytotoxicity against human HEK293 cells assessed as cell viability at 100 uM measured after 24 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as cell viability at 100 uM measured after 24 hrs by MTT assay
[PMID: 35849534]
HepG2 CC50
> 100 μM
Compound: Sinefungin
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by neutral red uptake assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by neutral red uptake assay
[PMID: 34257831]
Sf9 IC50
8.6 μM
Compound: 1
Inhibition of full-length N-terminal FLAG-tagged PRMT5 (unknown origin) (1 to 637 residues) expressed in baculovirus infected Sf9 insect cells using histone H4 as peptide after 5 hrs in presence of [H3]AdoMet by scintillation proximity assay
Inhibition of full-length N-terminal FLAG-tagged PRMT5 (unknown origin) (1 to 637 residues) expressed in baculovirus infected Sf9 insect cells using histone H4 as peptide after 5 hrs in presence of [H3]AdoMet by scintillation proximity assay
[PMID: 30366617]
體外研究
(In Vitro)

Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Renal epithelial cells.
Concentration: 0.5 or 1.0 μg/mL.
Incubation Time: Pretreatment 60 minutes before TGF-β1 (10 ng/mL).
Result: Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.
體內(nèi)研究
(In Vivo)

Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (8 weeks of age)[2].
Dosage: 10 mg/kg
Administration: Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).
Result: Inhibited α-SMA protein expression.
Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.
分子量

381.39

Formula

C15H23N7O5
CAS 號
性狀

固體

顏色

White to yellow

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實驗： 

H2O 中的溶解度 : 100 mg/mL (262.20 mM; 超聲助溶)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.6220 mL 13.1099 mL 26.2199 mL
5 mM 0.5244 mL 2.6220 mL 5.2440 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.91%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6220 mL 13.1099 mL 26.2199 mL 65.5497 mL
5 mM 0.5244 mL 2.6220 mL 5.2440 mL 13.1099 mL
10 mM 0.2622 mL 1.3110 mL 2.6220 mL 6.5550 mL
15 mM 0.1748 mL 0.8740 mL 1.7480 mL 4.3700 mL
20 mM 0.1311 mL 0.6555 mL 1.3110 mL 3.2775 mL
25 mM 0.1049 mL 0.5244 mL 1.0488 mL 2.6220 mL
30 mM 0.0874 mL 0.4370 mL 0.8740 mL 2.1850 mL
40 mM 0.0655 mL 0.3277 mL 0.6555 mL 1.6387 mL
50 mM 0.0524 mL 0.2622 mL 0.5244 mL 1.3110 mL
60 mM 0.0437 mL 0.2185 mL 0.4370 mL 1.0925 mL
80 mM 0.0328 mL 0.1639 mL 0.3277 mL 0.8194 mL
100 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.6555 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Sinefungin
目錄號：
HY-101938
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