巴格列酮
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- CAS號(hào):
- 199113-98-9
- 英文名:
- Balaglitazone
- 英文別名:
- Nn2344;Drf-2593;Drf 2593;Balaglitazone;Unii-4m1609828o;Balaglitazone [inn];DRF-2593;NN-2344;DRF2593;NN2344;DRF 2593;NN 2344;5-[[4-[(3-methyl-4-oxoquinazolin-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;(+/-)-5-(p-((3,4-Dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy)benzyl)-2,4-thiazolidinedione;5-[[4-[(3,4-dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy]phenyl]methyl]-2,4-Thiazolidinedione
- 中文名:
- 巴格列酮
- 中文別名:
- 巴格列酮;5-(4-((3-甲基-4-氧代-3,4-二氫喹唑啉-2-基)甲氧基)芐基)噻唑烷-2,4-二酮
- CBNumber:
- CB31465782
- 分子式:
- C20H17N3O4S
- 分子量:
- 395.43
- MOL File:
- 199113-98-9.mol
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巴格列酮化學(xué)性質(zhì)
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密度:
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1.45±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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insoluble in H2O; ≥15.45 mg/mL in DMSO; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic
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形態(tài):
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solid
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酸度系數(shù)(pKa):
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6.33±0.50(Predicted)
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顏色:
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Light yellow to yellow
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巴格列酮性質(zhì)、用途與生產(chǎn)工藝
Balaglitazone 是一種選擇性的 PPARγ 部分激動(dòng)劑，對(duì)人 PPARγ 的 EC50 值為 1.351 μM。
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PPARγ
351 nM (EC
50
, Human PPARγ)
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Balaglitazone is a selective partial PPARγ agonist with an EC
50
of 1.351 μM. Balaglitazone (5-100 μM) has equal cytotoxicity towards K562 and K562/DOX cells. Balaglitazone decreases doxorubicin cytotoxicity in K562 and K562/DOX cells, with IC
50
s of 0.117 μM and 0.53 μM, respectively. Balaglitazone reverses multidrug resistance (MDR) in K562/DOX cells. Balaglitazone (25 μM) increases Rh123 accumulation in K562/DOX cells, but does not increases MFI in K562 cells. Balaglitazone downregulates P-gp expression in K562/DOX cells, and such effects are via upregulation of PTEN in K562/DOX cells, and be abolished by PTEN inhibition.
Balaglitazone (3 mg/kg, p.o.) shows antihyperglycaemic activity in fully diabetic and insulin resistant db/db mice, and is more potent than the full PPARγ agonist rosiglitazone. Balaglitazone (10 mg/kg, p.o.) suppresses overall glucose, decreases insulin levels, and increases bodyweight in male diet-induced obese rats, and such effects are equal to that of 30 mg/kg pioglitazone.
巴格列酮
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2024/11/08 | HY-16086 | 巴格列酮
Balaglitazone | 199113-98-9 | 5mg | 1900元 |
| 2024/11/08 | HY-16086 | 巴格列酮
Balaglitazone | 199113-98-9 | 10mM * 1mLin DMSO | 2090元 |
199113-98-9, 巴格列酮 相關(guān)搜索:
- APIs
- 抑制劑
- 藥靶配體
- 細(xì)胞周期
- 原料藥
- 5-(4-((3-甲基-4-氧代-3,4-二氫喹唑啉-2-基)甲氧基)芐基)噻唑烷-2,4-二酮
- 巴格列酮
- 199113-98-9
- 5-[[4-[(3-methyl-4-oxoquinazolin-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
- DRF-2593;NN-2344;DRF2593;NN2344;DRF 2593;NN 2344
- 5-[[4-[(3,4-dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy]phenyl]methyl]-2,4-Thiazolidinedione
- 5-[[4-[[3-Methyl-4-oxo-3,4-dihydro-2-quinazolinyl]methoxy]phenyl]methyl]thiazolidine-2,4-dione
- Unii-4m1609828o
- Nn2344
- Drf-2593
- Drf 2593
- Balaglitazone [inn]
- (+/-)-5-(p-((3,4-Dihydro-3-methyl-4-oxo-2-quinazolinyl)methoxy)benzyl)-2,4-thiazolidinedione
- 2,4-Thiazolidinedione,5-[[4-[(3,4-dihydro-3-methyl-4-oxo-2-quinazolinyl) methoxy]phenyl]methyl]-
- Balaglitazone