2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
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- CAS號:
- 111686-79-4
- 英文名:
- 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
- 英文別名:
- pr934-423a;fpl12924aa;RemacemideHCl;REMACEMIDE HYDROCHLORIDE;2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride;2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE;2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-;2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid
- 中文名:
- 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
- 中文別名:
- 鹽酸瑞馬酰胺;化合物 T23231;2-氨基-N-(1-甲基-1,2-二苯乙基)乙酰胺鹽酸鹽
- CBNumber:
- CB2360100
- 分子式:
- C17H21ClN2O
- 分子量:
- 304.82
- MOL File:
- 111686-79-4.mol
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE化學(xué)性質(zhì)
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熔點(diǎn):
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253-254°
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儲存條件:
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room temp
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溶解度:
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H2O: >10mg/mL
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形態(tài):
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powder
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顏色:
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white to beige
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水溶解性:
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Soluble to 100 mM in water
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE性質(zhì)、用途與生產(chǎn)工藝
Remacemide hydrochloride (FPL 12924AA) 是一種鈉離子通道的中等強(qiáng)度抑制劑，是 N-methyl-D-aspartate (NMDA) 受體 的弱無競爭力拮抗劑，對于 MK-801 結(jié)合的 IC50 值為 68 μM，對于 NMDA 電流的 IC50 值為 76 μM。Remacemide hydrochloride 是一種抗驚厥劑。
IC50: 68-76 μM (NMDA receptor)
IC50:160.6 μM(sodium channel)
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na
+
channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC
50
value of 160.6 μM.
Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats.
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Animal Model:
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Female Sprague–Dawley rats ( 190-210 g )
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Dosage:
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100 mg/kg and 150 mg/kg
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Administration:
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Orogastric gavage; once a day; 7 days
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Result:
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Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
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2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
生產(chǎn)廠家
111686-79-4, 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE 相關(guān)搜索:
- 抑制劑
- 2-氨基-N-(1-甲基-1,2-二苯乙基)乙酰胺鹽酸鹽
- 化合物 T23231
- 鹽酸瑞馬酰胺
- 111686-79-4
- pr934-423a
- fpl12924aa
- 2-diphenylethyl)acetamidemonohydrochloride(+-)-2-amino-n-(1-methyl-
- 2-amino-n-(1-methyl-1,2-diphenylethyl)-,monohydrochloride,(+-)-acetamid
- 2-AMino-N-(1,2-diphenylpropan-2-yl)acetaMide hydrochloride
- RemacemideHCl
- 2-AMINO-N-(1-METHYL-1,2-DIPHENYLETHYL)ACETAMIDE HYDROCHLORIDE
- REMACEMIDE HYDROCHLORIDE